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Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He

Horst, Felix ; Schardt, Dieter ; Iwase, Hiroshi ; Schuy, Christoph ; Durante, Marco ; Weber, Uli (2024)
Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He.
In: Physics in Medicine & Biology, 2021, 66 (9)
doi: 10.26083/tuprints-00020501
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He
Language: English
Date: 5 March 2024
Place of Publication: Darmstadt
Year of primary publication: 2021
Place of primary publication: Bristol
Publisher: IOP Publishing
Journal or Publication Title: Physics in Medicine & Biology
Volume of the journal: 66
Issue Number: 9
Collation: 16 Seiten
DOI: 10.26083/tuprints-00020501
Corresponding Links:
Origin: Secondary publication DeepGreen
Abstract:

There is increasing interest in using helium ions for radiotherapy, complementary to protons and carbon ions. A large number of patients were treated with ⁴He ions in the US heavy ion therapy project and novel ⁴He ion treatment programs are under preparation, for instance in Germany and Japan. ³He ions have been proposed as an alternative to ⁴He ions because the acceleration of ³He is technically less difficult than ⁴He. In particular, beam contaminations have been pointed out as a potential safety issue for ⁴He ion beams. This motivated a series of experiments with ³He ion beams at Gesellschaft für Schwerionenforschung (GSI), Darmstadt. Measured ³He Bragg curves and fragmentation data in water are presented in this work. Those experimental data are compared with FLUKA Monte Carlo simulations. The physical characteristics of ³He ion beams are compared to those of ⁴He, for which a large set of data became available in recent years from the preparation work at the Heidelberger Ionenstrahl-Therapiezentrum (HIT). The dose distributions (spread out Bragg peaks, lateral profiles) that can be achieved with ³He ions are found to be competitive to ⁴He dose distributions. The effect of beam contaminations on ⁴He depth dose distribution is also addressed. It is concluded that ³He ions can be a viable alternative to ⁴He, especially for future compact therapy accelerator designs and upgrades of existing ion therapy facilities.

Uncontrolled Keywords: helium ion therapy, particle therapy, Bragg curve, nuclear fragmentation, heavy ion therapy, Monte Carlo simulation
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-205018
Classification DDC: 500 Science and mathematics > 530 Physics
600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 05 Mar 2024 12:55
Last Modified: 05 Mar 2024 12:56
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/20501
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