Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix (2019)
FKBP Ligands—Where We Are and Where to Go?
In: Frontiers in Pharmacology, 2018, 9
Article, Secondary publication, Publisher's Version
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| Item Type: | Article |
|---|---|
| Type of entry: | Secondary publication |
| Title: | FKBP Ligands—Where We Are and Where to Go? |
| Language: | English |
| Date: | 21 February 2019 |
| Place of Publication: | Darmstadt |
| Year of primary publication: | 2018 |
| Publisher: | Frontiers |
| Journal or Publication Title: | Frontiers in Pharmacology |
| Volume of the journal: | 9 |
| Corresponding Links: | |
| Origin: | Secondary publication via sponsored Golden Open Access |
| Abstract: | In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers. |
| Status: | Publisher's Version |
| URN: | urn:nbn:de:tuda-tuprints-85010 |
| Classification DDC: | 500 Science and mathematics > 540 Chemistry |
| Divisions: | 07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie |
| Date Deposited: | 21 Feb 2019 10:30 |
| Last Modified: | 20 Oct 2023 09:00 |
| URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/8501 |
| PPN: | |
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