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An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates

Kilb, Michelle Fiona ; Moos, Yannik ; Eckes, Stefanie ; Braun, Joy ; Ritz, Ulrike ; Nickel, Daniela ; Schmitz, Katja (2022)
An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates.
In: Biomedicines, 2022, 9 (11)
doi: 10.26083/tuprints-00020067
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates
Language: English
Date: 29 April 2022
Place of Publication: Darmstadt
Year of primary publication: 2022
Publisher: MDPI
Journal or Publication Title: Biomedicines
Volume of the journal: 9
Issue Number: 11
Collation: 13 Seiten
DOI: 10.26083/tuprints-00020067
Corresponding Links:
Origin: Secondary publication DeepGreen
Abstract:

The controlled release of antibiotics prevents the spread of pathogens and thereby improves healing processes in regenerative medicine. However, high concentrations may interfere with healing processes. It is therefore advantageous to use biodegradable materials for a controlled release. In particular, multilayer materials enable differential release at different surfaces. For this purpose, collagen sheets of different properties can be bonded by photochemical crosslinking. Here, we present the development and application of an easily accessible, additively manufactured sample holder to study the controlled release of vancomycin from modularly assembled collagen laminates in two directions. As proof-of-concept, we show that laminates of collagen sheets covalently linked by rose bengal and green light crosslinking (RGX) can be tightly inserted into the device without leakage from the upper to lower cavity. We used this sample holder to detect the release of vancomycin from symmetrically and asymmetrically loaded two-layer and three-layer collagen laminates into the upper and lower cavity of the sample holder. We show that these collagen laminates are characterized by a collagen type-dependent vancomycin release, enabling the control of antibiotic release profiles as well as the direction of antibiotic release.

Uncontrolled Keywords: collagen, controlled release, crosslinking, vancomycin, additively manufactured sample holder
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-200673
Classification DDC: 500 Science and mathematics > 540 Chemistry
600 Technology, medicine, applied sciences > 610 Medicine and health
600 Technology, medicine, applied sciences > 620 Engineering and machine engineering
Divisions: 07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie
07 Department of Chemistry > Clemens-Schöpf-Institut > Organ Chemistry
Date Deposited: 29 Apr 2022 08:47
Last Modified: 14 Nov 2023 19:04
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/20067
PPN: 500227659
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