Elbakry, Amira ; Löbrich, Markus (2021)
Homologous Recombination Subpathways: A Tangle to Resolve.
In: Frontiers in Genetics, 2021, 12
doi: 10.26083/tuprints-00019438
Article, Secondary publication, Publisher's Version
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| Item Type: | Article |
|---|---|
| Type of entry: | Secondary publication |
| Title: | Homologous Recombination Subpathways: A Tangle to Resolve |
| Language: | English |
| Date: | 3 September 2021 |
| Place of Publication: | Darmstadt |
| Year of primary publication: | 2021 |
| Publisher: | Frontiers |
| Journal or Publication Title: | Frontiers in Genetics |
| Volume of the journal: | 12 |
| Collation: | 7 Seiten |
| DOI: | 10.26083/tuprints-00019438 |
| Corresponding Links: | |
| Origin: | Secondary publication via sponsored Golden Open Access |
| Abstract: | Homologous recombination (HR) is an essential pathway for DNA double-strand break (DSB) repair, which can proceed through various subpathways that have distinct elements and genetic outcomes. In this mini-review, we highlight the main features known about HR subpathways operating at DSBs in human cells and the factors regulating subpathway choice. We examine new developments that provide alternative models of subpathway usage in different cell types revise the nature of HR intermediates involved and reassess the frequency of repair outcomes. We discuss the impact of expanding our understanding of HR subpathways and how it can be clinically exploited. |
| Status: | Publisher's Version |
| URN: | urn:nbn:de:tuda-tuprints-194381 |
| Additional Information: | Keywords: homologous recombination, pathway choice, synthesis-dependent strand annealing, ATRX, RECQ5, double-strand break, holliday junction, crossover |
| Classification DDC: | 500 Science and mathematics > 570 Life sciences, biology |
| Divisions: | 10 Department of Biology > Radiation Biology and DNA Repair |
| Date Deposited: | 03 Sep 2021 12:33 |
| Last Modified: | 14 Nov 2023 19:04 |
| URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/19438 |
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