TU Darmstadt / ULB / TUprints

Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview

Lermyte, Frederik (2021)
Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview.
In: Life, 2020, 10 (12)
doi: 10.26083/tuprints-00019275
Article, Secondary publication, Publisher's Version

[img]
Preview
Text
life-10-00320-v3.pdf
Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

Download (3MB) | Preview
Item Type: Article
Type of entry: Secondary publication
Title: Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview
Language: English
Date: 9 August 2021
Place of Publication: Darmstadt
Year of primary publication: 2020
Publisher: MDPI
Journal or Publication Title: Life
Volume of the journal: 10
Issue Number: 12
Collation: 19 Seiten
DOI: 10.26083/tuprints-00019275
Corresponding Links:
Origin: Secondary publication via sponsored Golden Open Access
Abstract:

In recent years, there has been a growing understanding that a significant fraction of the eukaryotic proteome is intrinsically disordered, and that these conformationally dynamic proteins play a myriad of vital biological roles in both normal and pathological states. In this review, selected examples of intrinsically disordered proteins are highlighted, with particular attention for a few which are relevant in neurological disorders and in viral infection. Next, the underlying causes for intrinsic disorder are discussed, along with computational methods used to predict whether a given amino acid sequence is likely to adopt a folded or unfolded state in solution. Finally, biophysical methods for the analysis of intrinsically disordered proteins will be discussed, as well as the unique challenges they pose in this context due to their highly dynamic nature.

Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-192758
Classification DDC: 500 Science and mathematics > 540 Chemistry
Divisions: 07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie
Date Deposited: 09 Aug 2021 08:01
Last Modified: 14 Nov 2023 19:03
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19275
PPN:
Export:
Actions (login required)
View Item View Item