Durante, Marco ; Schulze, Kai ; Incerti, Sebastien ; Francis, Ziad ; Zein, Sara ; Guzmán, Carlos Alberto (2024)
Virus Irradiation and COVID-19 Disease.
In: Frontiers in Physics, 2020, 8
doi: 10.26083/tuprints-00016724
Article, Secondary publication, Publisher's Version
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Item Type: | Article |
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Type of entry: | Secondary publication |
Title: | Virus Irradiation and COVID-19 Disease |
Language: | English |
Date: | 12 March 2024 |
Place of Publication: | Darmstadt |
Year of primary publication: | 20 October 2020 |
Place of primary publication: | Lausanne |
Publisher: | Frontiers Media S.A. |
Journal or Publication Title: | Frontiers in Physics |
Volume of the journal: | 8 |
Collation: | 7 Seiten |
DOI: | 10.26083/tuprints-00016724 |
Corresponding Links: | |
Origin: | Secondary publication DeepGreen |
Abstract: | Virus irradiation has been performed for many decades for basic research studies, sterilization, and vaccine development. The COVID-19 outbreak is currently causing an enormous effort worldwide for finding a vaccine against coronavirus. High doses of γ-rays can be used for the development of vaccines that exploit inactivated virus. This technique has been gradually replaced by more practical methods, in particular the use of chemicals, but irradiation remains a simple and effective method used in some cases. The technique employed for inactivating a virus has an impact on its ability to induce an adaptive immune response able to confer effective protection. We propose here that accelerated heavy ions can be used to inactivate SARS-CoV-2 viruses with small damage to the spike proteins of the envelope and can then provide an intact virion for vaccine development. |
Uncontrolled Keywords: | COVID-19, SARS-CoV-2, virus, gamma rays, heavy ions |
Identification Number: | Artikel-ID: 565861 |
Status: | Publisher's Version |
URN: | urn:nbn:de:tuda-tuprints-167245 |
Additional Information: | This article is part of the Research Topic: Applied Nuclear Physics at Accelerators Specialty section: This article was submitted to Medical Physics and Imaging, a section of the journal Frontiers in Physics |
Classification DDC: | 500 Science and mathematics > 530 Physics 500 Science and mathematics > 570 Life sciences, biology 600 Technology, medicine, applied sciences > 610 Medicine and health |
Divisions: | 05 Department of Physics > Institute for Condensed Matter Physics |
Date Deposited: | 12 Mar 2024 12:53 |
Last Modified: | 10 Jul 2024 15:13 |
SWORD Depositor: | Deep Green |
URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/16724 |
PPN: | 519720636 |
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