TU Darmstadt / ULB / TUprints

Virus Irradiation and COVID-19 Disease

Durante, Marco ; Schulze, Kai ; Incerti, Sebastien ; Francis, Ziad ; Zein, Sara ; Guzmán, Carlos Alberto (2024)
Virus Irradiation and COVID-19 Disease.
In: Frontiers in Physics, 2020, 8
doi: 10.26083/tuprints-00016724
Article, Secondary publication, Publisher's Version

[img]
Preview
Text
fphy-08-565861.pdf
Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

Download (1MB) | Preview
Item Type: Article
Type of entry: Secondary publication
Title: Virus Irradiation and COVID-19 Disease
Language: English
Date: 12 March 2024
Place of Publication: Darmstadt
Year of primary publication: 20 October 2020
Place of primary publication: Lausanne
Publisher: Frontiers Media S.A.
Journal or Publication Title: Frontiers in Physics
Volume of the journal: 8
Collation: 7 Seiten
DOI: 10.26083/tuprints-00016724
Corresponding Links:
Origin: Secondary publication DeepGreen
Abstract:

Virus irradiation has been performed for many decades for basic research studies, sterilization, and vaccine development. The COVID-19 outbreak is currently causing an enormous effort worldwide for finding a vaccine against coronavirus. High doses of γ-rays can be used for the development of vaccines that exploit inactivated virus. This technique has been gradually replaced by more practical methods, in particular the use of chemicals, but irradiation remains a simple and effective method used in some cases. The technique employed for inactivating a virus has an impact on its ability to induce an adaptive immune response able to confer effective protection. We propose here that accelerated heavy ions can be used to inactivate SARS-CoV-2 viruses with small damage to the spike proteins of the envelope and can then provide an intact virion for vaccine development.

Uncontrolled Keywords: COVID-19, SARS-CoV-2, virus, gamma rays, heavy ions
Identification Number: Artikel-ID: 565861
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-167245
Additional Information:

This article is part of the Research Topic: Applied Nuclear Physics at Accelerators

Specialty section: This article was submitted to Medical Physics and Imaging, a section of the journal Frontiers in Physics

Classification DDC: 500 Science and mathematics > 530 Physics
500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 12 Mar 2024 12:53
Last Modified: 10 Jul 2024 15:13
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/16724
PPN: 519720636
Export:
Actions (login required)
View Item View Item