TU Darmstadt / ULB / TUprints

FKBP Ligands—Where We Are and Where to Go?

Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix (2019)
FKBP Ligands—Where We Are and Where to Go?
In: Frontiers in Pharmacology, 2018, 9
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

Download (2MB) | Preview
Item Type: Article
Type of entry: Secondary publication
Title: FKBP Ligands—Where We Are and Where to Go?
Language: English
Date: 21 February 2019
Place of Publication: Darmstadt
Year of primary publication: 2018
Publisher: Frontiers
Journal or Publication Title: Frontiers in Pharmacology
Volume of the journal: 9
Corresponding Links:
Origin: Secondary publication via sponsored Golden Open Access

In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.

Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-85010
Classification DDC: 500 Science and mathematics > 540 Chemistry
Divisions: 07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie
Date Deposited: 21 Feb 2019 10:30
Last Modified: 20 Oct 2023 09:00
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/8501
Actions (login required)
View Item View Item