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FKBP Ligands—Where We Are and Where to Go?

Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix (2018):
FKBP Ligands—Where We Are and Where to Go?
In: Frontiers in Pharmacology, 9, Frontiers, ISSN 1663-9812,

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Origin: Secondary publication via sponsored Golden Open Access
Title: FKBP Ligands—Where We Are and Where to Go?
Language: English

In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.

Journal or Publication Title: Frontiers in Pharmacology
Volume of the journal: 9
Place of Publication: Darmstadt
Publisher: Frontiers
Classification DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Divisions: 07 Department of Chemistry > Fachgebiet Biochemie
Date Deposited: 21 Feb 2019 10:30
Last Modified: 13 Dec 2022 10:26
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-85010
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/8501
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