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Novel amino‐Li resin for water‐based solid‐phase peptide synthesis

Uth, Christina ; Englert, Simon ; Avrutina, Olga ; Kolmar, Harald ; Knauer, Sascha (2024)
Novel amino‐Li resin for water‐based solid‐phase peptide synthesis.
In: Journal of Peptide Science, 2023, 29 (12)
doi: 10.26083/tuprints-00027214
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Novel amino‐Li resin for water‐based solid‐phase peptide synthesis
Language: English
Date: 28 May 2024
Place of Publication: Darmstadt
Year of primary publication: December 2023
Place of primary publication: New York
Publisher: John Wiley & Sons
Journal or Publication Title: Journal of Peptide Science
Volume of the journal: 29
Issue Number: 12
Collation: 7 Seiten
DOI: 10.26083/tuprints-00027214
Corresponding Links:
Origin: Secondary publication DeepGreen

We report the first application of a novel amino‐Li resin to water‐based solid‐phase peptide synthesis (SPPS) applying the Smoc‐protecting group approach. We demonstrated that it is a suitable support for the sustainable water‐based alternative to a classical SPPS approach. The resin possesses good swelling properties in aqueous milieu, provides significant coupling sites, and may be applicable to the synthesis of difficult sequences and aggregation‐prone peptides.

Uncontrolled Keywords: ASPPS, Smoc strategy, solid support, sustainable peptide synthesis, water‐based peptide synthesis
Identification Number: Artikel-ID: e3527
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-272142
Additional Information:

Dedicated to the memory of Michael Przybylski.

Classification DDC: 500 Science and mathematics > 540 Chemistry
500 Science and mathematics > 570 Life sciences, biology
Divisions: 07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie
Date Deposited: 28 May 2024 11:49
Last Modified: 28 May 2024 11:49
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/27214
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