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Peptide‐Reinforced Amphiphilic Polymer Conetworks

Velasquez, Sara T. R. ; Jang, Daseul ; Jenkins, Peter ; Liu, Peng ; Yang, Liu ; Korley, LaShanda T. J. ; Bruns, Nico (2024)
Peptide‐Reinforced Amphiphilic Polymer Conetworks.
In: Advanced Functional Materials, 2022, 32 (51)
doi: 10.26083/tuprints-00023688
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Item Type: Article
Type of entry: Secondary publication
Title: Peptide‐Reinforced Amphiphilic Polymer Conetworks
Language: English
Date: 22 January 2024
Place of Publication: Darmstadt
Year of primary publication: 2022
Place of primary publication: Weinheim
Publisher: Wiley-VCH
Journal or Publication Title: Advanced Functional Materials
Volume of the journal: 32
Issue Number: 51
Collation: 15 Seiten
DOI: 10.26083/tuprints-00023688
Corresponding Links:
Origin: Secondary publication DeepGreen

Amphiphilic polymer conetworks (APCNs) are polymer networks composed of hydrophilic and hydrophobic chain segments. Their applications range from soft contact lenses to membranes and biomaterials. APCNs based on polydimethylsiloxane (PDMS) and poly(2‐hydroxyethyl acrylate) are flexible and elastic in the dry and swollen state. However, they are not good at resisting deformation under load, i.e., their toughness is low. A bio‐inspired approach to reinforce APCNs is presented based on the incorporation of poly(β‐benzyl‐L‐aspartate) (PBLA) blocks between cross‐linking points and PDMS chain segments. The mechanical properties of the resulting peptide‐reinforced APCNs can be tailored by the secondary structure of the peptide chains (β‐sheets or a mixture of α‐helices and β‐sheets). Compared to non‐reinforced APCNs, the peptide‐reinforced networks have higher extensibility (53 vs. up to 341%), strength (0.71 ± 0.16 vs. 22.28 ± 2.81 MPa), and toughness (0.10 ± 0.04 vs. up to 4.85 ± 1.32 MJ m⁻³), as measured in their dry state. The PBLA peptides reversibly toughen and reinforce the APCNs, while other key material properties of APCNs are retained, such as optical transparency and swellability in water and organic solvents. This paves the way for applications of APCNs that benefit from significantly increased mechanical properties.

Uncontrolled Keywords: amphiphilic polymer networks, bio‐inspired polymeric materials, hydrogels, mechanical properties, peptide‐polymer hybrids, peptides, polymer reinforcements
Identification Number: 2207317
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-236881
Classification DDC: 500 Science and mathematics > 540 Chemistry
600 Technology, medicine, applied sciences > 660 Chemical engineering
Divisions: Interdisziplinäre Forschungsprojekte > Centre for Synthetic Biology
07 Department of Chemistry > Ernst-Berl-Institut > Fachgebiet Makromolekulare Chemie
Date Deposited: 22 Jan 2024 13:50
Last Modified: 24 Jan 2024 08:31
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/23688
PPN: 514919477
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