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The guardian's choice: how p53 enables context‐specific decision‐making in individual cells

Friedel, Laura ; Loewer, Alexander (2023)
The guardian's choice: how p53 enables context‐specific decision‐making in individual cells.
In: The FEBS Journal, 2021, 289 (1)
doi: 10.26083/tuprints-00020129
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: The guardian's choice: how p53 enables context‐specific decision‐making in individual cells
Language: English
Date: 22 December 2023
Place of Publication: Darmstadt
Year of primary publication: 2021
Place of primary publication: Oxford
Publisher: Wiley-Blackwell
Journal or Publication Title: The FEBS Journal
Volume of the journal: 289
Issue Number: 1
DOI: 10.26083/tuprints-00020129
Corresponding Links:
Origin: Secondary publication DeepGreen

p53 plays a central role in defending the genomic integrity of our cells. In response to genotoxic stress, this tumour suppressor orchestrates the expression of hundreds of target genes, which induce a variety of cellular outcomes ranging from damage repair to induction of apoptosis. In this review, we examine how the p53 response is regulated on several levels in individual cells to allow precise and context‐specific fate decisions. We discuss that the p53 response is not only controlled by its canonical regulators but also controlled by interconnected signalling pathways that influence the dynamics of p53 accumulation upon damage and modulate its transcriptional activity at target gene promoters. Additionally, we consider how the p53 response is diversified through a variety of mechanisms at the promoter level and beyond to induce context‐specific outcomes in individual cells. These layers of regulation allow p53 to react in a stimulus‐specific manner and fine‐tune its signalling according to the individual needs of a given cell, enabling it to take the right decision on survival or death.

Uncontrolled Keywords: apoptosis, cell cycle arrest, DNA damage response, p53, post‐transcriptional modifications, protein dynamics, signalling crosstalk, single cell analysis, stochastic gene expression
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-201298
Additional Information:

This article also appears in: State-of-the-Art Reviews

Classification DDC: 500 Science and mathematics > 570 Life sciences, biology
Divisions: 10 Department of Biology > Systems Biology of the Stress Response
Date Deposited: 22 Dec 2023 13:38
Last Modified: 08 Mar 2024 07:42
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/20129
PPN: 516075187
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