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Homologous Recombination Subpathways: A Tangle to Resolve

Elbakry, Amira ; Löbrich, Markus (2021)
Homologous Recombination Subpathways: A Tangle to Resolve.
In: Frontiers in Genetics, 2021, 12
doi: 10.26083/tuprints-00019438
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Type of entry: Secondary publication
Title: Homologous Recombination Subpathways: A Tangle to Resolve
Language: English
Date: 3 September 2021
Place of Publication: Darmstadt
Year of primary publication: 2021
Publisher: Frontiers
Journal or Publication Title: Frontiers in Genetics
Volume of the journal: 12
Collation: 7 Seiten
DOI: 10.26083/tuprints-00019438
Corresponding Links:
Origin: Secondary publication via sponsored Golden Open Access

Homologous recombination (HR) is an essential pathway for DNA double-strand break (DSB) repair, which can proceed through various subpathways that have distinct elements and genetic outcomes. In this mini-review, we highlight the main features known about HR subpathways operating at DSBs in human cells and the factors regulating subpathway choice. We examine new developments that provide alternative models of subpathway usage in different cell types revise the nature of HR intermediates involved and reassess the frequency of repair outcomes. We discuss the impact of expanding our understanding of HR subpathways and how it can be clinically exploited.

Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-194381
Additional Information:

Keywords: homologous recombination, pathway choice, synthesis-dependent strand annealing, ATRX, RECQ5, double-strand break, holliday junction, crossover

Classification DDC: 500 Science and mathematics > 570 Life sciences, biology
Divisions: 10 Department of Biology > Radiation Biology and DNA Repair
Date Deposited: 03 Sep 2021 12:33
Last Modified: 14 Nov 2023 19:04
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19438
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