Schmidt, Annika ; Zhang, Hui ; Cardoso, M. Cristina (2020):
MeCP2 and Chromatin Compartmentalization.
In: Cells, 9 (4), MDPI, ISSN 2073-4409,
DOI: 10.25534/tuprints-00013360,
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Item Type: | Article |
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Origin: | Secondary publication via sponsored Golden Open Access |
Title: | MeCP2 and Chromatin Compartmentalization |
Language: | English |
Abstract: | Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address how these properties regulate and mediate the ability of MeCP2 to orchestrate chromatin compartmentalization and higher order genome architecture. |
Journal or Publication Title: | Cells |
Volume of the journal: | 9 |
Issue Number: | 4 |
Publisher: | MDPI |
Classification DDC: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
Divisions: | 10 Department of Biology > Cell Biology and Epigenetics |
Date Deposited: | 25 Aug 2020 09:22 |
Last Modified: | 25 Aug 2020 09:54 |
DOI: | 10.25534/tuprints-00013360 |
URL / URN: | https://doi.org/10.3390/cells9040878 |
URN: | urn:nbn:de:tuda-tuprints-133604 |
URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/13360 |
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