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MeCP2 and Chromatin Compartmentalization

Schmidt, Annika ; Zhang, Hui ; Cardoso, M. Cristina (2020):
MeCP2 and Chromatin Compartmentalization.
In: Cells, 9 (4), MDPI, ISSN 2073-4409,
DOI: 10.25534/tuprints-00013360,

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Origin: Secondary publication via sponsored Golden Open Access
Title: MeCP2 and Chromatin Compartmentalization
Language: English

Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address how these properties regulate and mediate the ability of MeCP2 to orchestrate chromatin compartmentalization and higher order genome architecture.

Journal or Publication Title: Cells
Volume of the journal: 9
Issue Number: 4
Publisher: MDPI
Classification DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
Divisions: 10 Department of Biology > Cell Biology and Epigenetics
Date Deposited: 25 Aug 2020 09:22
Last Modified: 25 Aug 2020 09:54
DOI: 10.25534/tuprints-00013360
URL / URN: https://doi.org/10.3390/cells9040878
URN: urn:nbn:de:tuda-tuprints-133604
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/13360
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