Nasu, Daichi (2016):
Non-Natural Elements for Peptide-Based Molecular Design, Structural Analysis, and Functional Modifications.
Darmstadt, Technische Universität Darmstadt,
[Ph.D. Thesis]
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Item Type: | Ph.D. Thesis | ||||
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Title: | Non-Natural Elements for Peptide-Based Molecular Design, Structural Analysis, and Functional Modifications | ||||
Language: | English | ||||
Abstract: | The present thesis summarizes three research projects addressing fundamental studies aimed on application of non-natural elements to design and synthesis of bioactive peptide mimetics, bioconjugates, and hybrid macromolecules. The study comprised computational and knowledge-based design, total synthesis, and evaluation of biologic activity as well as application to NMR-based structural analysis. Results summarized in the present work were reported in two scientific publications and should be considered as milestones for further investigations aimed on application of the discussed concepts to biomedical studies. |
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Place of Publication: | Darmstadt | ||||
Uncontrolled Keywords: | Peptide, Peptidomimetic, Bioorthogonal Chemistry, Protease Inhibitor, PHIP, Peptide Nucleic Acid | ||||
Classification DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
Divisions: | 07 Department of Chemistry 07 Department of Chemistry > Fachgebiet Biochemie |
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Date Deposited: | 25 Jan 2016 13:23 | ||||
Last Modified: | 09 Jul 2020 01:13 | ||||
URN: | urn:nbn:de:tuda-tuprints-52527 | ||||
Referees: | Kolmar, Prof. Harald ; Buntkowsky, Prof. Gerd | ||||
Date of oral examination: | 14 December 2015 | ||||
URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/5252 | ||||
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