TU Darmstadt / ULB / TUprints

Electron-Beam-Initiated Crosslinking of Methacrylated Alginate and Diacrylated Poly(ethylene glycol) Hydrogels

Mignon, Arn ; Zimmer, Joanne ; Gutierrez Cisneros, Carolina ; Kühnert, Mathias ; Derveaux, Elien ; Daikos, Olesya ; Scherzer, Tom ; Adriaensens, Peter ; Schulze, Agnes (2024)
Electron-Beam-Initiated Crosslinking of Methacrylated Alginate and Diacrylated Poly(ethylene glycol) Hydrogels.
In: Polymers, 2023, 15 (24)
doi: 10.26083/tuprints-00027171
Article, Secondary publication, Publisher's Version

[img] Text
polymers-15-04685.pdf
Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

Download (3MB)
[img] Text (Supplement)
polymers-2680369-supplementary.pdf
Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

Download (1MB)
Item Type: Article
Type of entry: Secondary publication
Title: Electron-Beam-Initiated Crosslinking of Methacrylated Alginate and Diacrylated Poly(ethylene glycol) Hydrogels
Language: English
Date: 13 May 2024
Place of Publication: Darmstadt
Year of primary publication: 12 December 2023
Place of primary publication: Basel
Publisher: MDPI
Journal or Publication Title: Polymers
Volume of the journal: 15
Issue Number: 24
Collation: 14 Seiten
DOI: 10.26083/tuprints-00027171
Corresponding Links:
Origin: Secondary publication DeepGreen
Abstract:

An ideal wound dressing not only needs to absorb excess exudate but should also allow for a moist wound-healing environment as well as being mechanically strong. Such a dressing can be achieved by combining both a natural (alginate) and synthetic (poly(ethylene glycol) polymer. Interestingly, using an electron beam on (meth)acrylated polymers allows their covalent crosslinking without the use of toxic photo-initiators. The goal of this work was to crosslink alginate at different methacrylation degrees (26.1 and 53.5% of the repeating units) with diacrylated poly(ethylene glycol) (PEGDA) using electron-beam irradiation at different doses to create strong, transparent hydrogels. Infrared spectroscopy showed that both polymers were homogeneously distributed within the irradiated hydrogel. Rheology showed that the addition of PEGDA into alginate with a high degree of methacrylation and a polymer concentration of 6 wt/v% improved the storage modulus up to 15,867 ± 1102 Pa. Gel fractions > 90% and swelling ratios ranging from 10 to 250 times its own weight were obtained. It was observed that the higher the storage modulus, the more limited the swelling ratio due to a more crosslinked network. Finally, all species were highly transparent, with transmittance values > 80%. This may be beneficial for the visual inspection of healing progression. Furthermore, these polymers may eventually be used as carriers of photosensitizers, which is favorable in applications such as photodynamic therapy.

Uncontrolled Keywords: alginate, poly(ethylene glycol), (meth)acrylates, electron beam, physicochemical characterization, transparency, rheology
Identification Number: Artikel-ID: 4685
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-271713
Additional Information:

This article belongs to the Special Issue Smart Natural-Based Polymers

Classification DDC: 500 Science and mathematics > 530 Physics
500 Science and mathematics > 540 Chemistry
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 13 May 2024 12:42
Last Modified: 19 Sep 2024 09:37
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/27171
PPN: 521570603
Export:
Actions (login required)
View Item View Item