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Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?

Sokol, Olga ; Durante, Marco (2024)
Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?
In: Cancers, 2023, 15 (18)
doi: 10.26083/tuprints-00024638
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?
Language: English
Date: 19 January 2024
Place of Publication: Darmstadt
Year of primary publication: 2023
Place of primary publication: Basel
Publisher: MDPI
Journal or Publication Title: Cancers
Volume of the journal: 15
Issue Number: 18
Collation: 18 Seiten
DOI: 10.26083/tuprints-00024638
Corresponding Links:
Origin: Secondary publication DeepGreen

Hypoxia, which is associated with abnormal vessel growth, is a characteristic feature of many solid tumors that increases their metastatic potential and resistance to radiotherapy. Carbon-ion radiation therapy, either alone or in combination with other treatments, is one of the most promising treatments for hypoxic tumors because the oxygen enhancement ratio decreases with increasing particle LET. Nevertheless, current clinical practice does not yet fully benefit from the use of carbon ions to tackle hypoxia. Here, we provide an overview of the existing experimental and clinical evidence supporting the efficacy of C-ion radiotherapy in overcoming hypoxia-induced radioresistance, followed by a discussion of the strategies proposed to enhance it, including different approaches to maximize LET in the tumors.

Alternative Abstract:
Alternative AbstractLanguage

Carbon-ion radiotherapy is a potential elective treatment option for hypoxic tumors. Its high linear energy transfer enables enhanced cell killing in radiation-resistant tumors, while the Bragg peak ensures precise targeting. Clinical evidence in pancreatic and cervical cancers supports positive outcomes of carbon treatments. However, the power of carbon ions against tumor hypoxia is generally underexploited and should be considered to improve the clinical benefit.

Uncontrolled Keywords: hypoxia, carbon ions, CIRT, LET painting, particle therapy, radiotherapy
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-246387
Additional Information:

This article belongs to the Special Issue Carbon Ion Radiotherapy

Classification DDC: 500 Science and mathematics > 530 Physics
500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics > Biophysics
Date Deposited: 19 Jan 2024 13:57
Last Modified: 14 Feb 2024 07:30
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/24638
PPN: 515537772
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