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Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems

Fritschen, Anna ; Blaeser, Andreas (2023)
Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems.
In: Biomaterials, 2021, 268
doi: 10.26083/tuprints-00024336
Article, Secondary publication, Postprint

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Item Type: Article
Type of entry: Secondary publication
Title: Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems
Language: English
Date: 17 July 2023
Place of Publication: Darmstadt
Year of primary publication: 2021
Publisher: Elsevier
Journal or Publication Title: Biomaterials
Volume of the journal: 268
Collation: 34 ungezählte Seiten
DOI: 10.26083/tuprints-00024336
Corresponding Links:
Origin: Secondary publication service

Organ-on-a-Chip (OOC) devices have seen major advances in the last years with respect to biological complexity, physiological composition and biomedical relevance. In this context, integration of vasculature has proven to be a crucial element for long-term culture of thick tissue samples as well as for realistic pharmacokinetic, toxicity and metabolic modelling. With the emergence of digital production technologies and the reinvention of existing tools, a multitude of design approaches for guided angio- and vasculogenesis is available today. The underlying production methods can be categorized into biosynthetic, biomimetic and self-assembled vasculature formation. The diversity and importance of production approaches, vascularization strategies as well as biomaterials and cell sourcing are illustrated in this work. A comprehensive technological review with a strong focus on the challenge of producing physiologically relevant vascular structures is given. Finally, the remaining obstacles and opportunities in the development of vascularized Organ-on-a-Chip platforms for advancing drug development and predictive disease modelling are noted.

Status: Postprint
URN: urn:nbn:de:tuda-tuprints-243367
Classification DDC: 500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 620 Engineering and machine engineering
Divisions: 16 Department of Mechanical Engineering > Institute of Printing Science and Technology (IDD) > Biomedical Printing Technology (BMT)
Date Deposited: 17 Jul 2023 12:09
Last Modified: 17 Oct 2023 07:30
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/24336
PPN: 51223705
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