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Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

Volz, Lennart ; Reidel, Claire-Anne ; Durante, Marco ; Prezado, Yolanda ; Schuy, Christoph ; Weber, Uli ; Graeff, Christian (2023)
Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors.
In: Instruments, 2023, 7 (2)
doi: 10.26083/tuprints-00024251
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors
Language: English
Date: 14 July 2023
Place of Publication: Darmstadt
Year of primary publication: 2023
Publisher: MDPI
Journal or Publication Title: Instruments
Volume of the journal: 7
Issue Number: 2
Collation: 20 Seiten
DOI: 10.26083/tuprints-00024251
Corresponding Links:
Origin: Secondary publication DeepGreen

Particle minibeam therapy has demonstrated the potential for better healthy tissue sparing due to spatial fractionation of the delivered dose. Especially for heavy ions, the spatial fractionation could enhance the already favorable differential biological effectiveness at the target and the entrance region. Moreover, spatial fractionation could even be a viable option for bringing ions heavier than carbon back into patient application. To understand the effect of minibeam therapy, however, requires careful conduction of pre-clinical experiments, for which precise knowledge of the minibeam characteristics is crucial. This work introduces the use of high-spatial-resolution CMOS sensors to characterize collimator-produced carbon ion minibeams in terms of lateral fluence distribution, secondary fragments, track-averaged linear energy transfer distribution, and collimator alignment. Additional simulations were performed to further analyze the parameter space of the carbon ion minibeams in terms of beam characteristics, collimator positioning, and collimator manufacturing accuracy. Finally, a new concept for reducing the neutron dose to the patient by means of an additional neutron shield added to the collimator setup is proposed and validated in simulation. The carbon ion minibeam collimator characterized in this work is used in ongoing pre-clinical experiments on heavy ion minibeam therapy at the GSI.

Uncontrolled Keywords: carbon ions, minibeams, CMOS sensors, particle therapy, minibeam collimator, neutron shield
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-242517
Additional Information:

This article belongs to the Special Issue Medical Applications of Particle Physics

Classification DDC: 500 Science and mathematics > 530 Physics
600 Technology, medicine, applied sciences > 620 Engineering and machine engineering
Divisions: 18 Department of Electrical Engineering and Information Technology > Technik der Strahlentherapie
05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 14 Jul 2023 11:18
Last Modified: 10 Oct 2023 09:07
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/24251
PPN: 512161224
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