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Parahydrogen‐Induced Polarization of Amino Acids

Pravdivtsev, Andrey N. ; Buntkowsky, Gerd ; Duckett, Simon B. ; Koptyug, Igor V. ; Hövener, Jan‐Bernd (2023)
Parahydrogen‐Induced Polarization of Amino Acids.
In: Angewandte Chemie International Edition, 2021, 60 (44)
doi: 10.26083/tuprints-00024215
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Parahydrogen‐Induced Polarization of Amino Acids
Language: English
Date: 13 July 2023
Place of Publication: Darmstadt
Year of primary publication: 2021
Publisher: Wiley
Journal or Publication Title: Angewandte Chemie International Edition
Volume of the journal: 60
Issue Number: 44
DOI: 10.26083/tuprints-00024215
Corresponding Links:
Origin: Secondary publication service

Nuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spin has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid-state NMR and metabolic imaging in vivo). Parahydrogen (pH₂) offers a fast and cost-efficient way to achieve hyperpolarization, and the last decade has seen extensive advances, including the synthesis of new tracers, catalysts, and transfer methods. The portfolio of hyperpolarized molecules now includes amino acids, which are of great interest for many applications. Here, we provide an overview of the current literature and developments in the hyperpolarization of amino acids and peptides.

Uncontrolled Keywords: amino acids, catalysis, hydrogenation, hyperpolarization, parahydrogen
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-242159
Classification DDC: 500 Science and mathematics > 530 Physics
500 Science and mathematics > 540 Chemistry
Divisions: 07 Department of Chemistry > Eduard Zintl-Institut > Physical Chemistry
Date Deposited: 13 Jul 2023 12:36
Last Modified: 04 Oct 2023 12:05
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/24215
PPN: 51200918X
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