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Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics

Richter, Merle ; Loth, Yannik ; Weisenstein, Christian ; Wigger, Anna Katharina ; Schaar, Dominik ; Bosserhoff, Anja Katrin ; Haring Bolívar, Peter (2023)
Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics.
In: Frequenz, 2022, 76 (11-12)
doi: 10.26083/tuprints-00023208
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics
Language: English
Date: 2023
Place of Publication: Darmstadt
Year of primary publication: 2022
Publisher: De Gruyter
Journal or Publication Title: Frequenz
Volume of the journal: 76
Issue Number: 11-12
DOI: 10.26083/tuprints-00023208
Corresponding Links:
Origin: Secondary publication

Terahertz (THz) biosensing has emerged as an important research field, mainly driven by the resonant behavior of many biomolecules in this spectral range which holds potential for highly sensitive analyses. In this work, we present a detailed overview of our current research on THz biosensing, focusing on the development and analysis of THz biosensors based on frequency selective surfaces (FSS) for two different measurement scenarios: i) label-free, highly sensitive and selective analysis of dried biomolecules, and ii) sensitive and selective analysis in an aqueous environment. With our carefully designed THz biosensor for measurements in the dry state, we were able to indirectly measure tumor-marker MIA RNA in a concentration as low as 1.55 × 1E−12 mol/L, without the need for biochemical amplification. Our biosensor with substrate-integrated microfluidics for terahertz measurements in an aqueous environment is validated by simulations, showing that the resonance feature in the frequency response of our sensor is maintained even for measurements in water.

Uncontrolled Keywords: biomedical spectroscopy, biosensing, fano resonance, metamaterial, microfluidics, terahertz
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-232089
Classification DDC: 500 Science and mathematics > 530 Physics
500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 600 Technology
600 Technology, medicine, applied sciences > 620 Engineering and machine engineering
Divisions: 18 Department of Electrical Engineering and Information Technology > Institute for Microwave Engineering and Photonics (IMP)
Date Deposited: 01 Mar 2023 10:15
Last Modified: 03 Mar 2023 09:39
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/23208
PPN: 505411709
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