All DNA transactions, including the repair of damaged DNA, take place in the context of a highly organized yet dynamic chromatin. While studies on individual proteins have yielded important insights into the constituent components of DNA repair machineries that evolved in various organisms, it has become abundantly clear that a more complete understanding of the molecular choreography of DNA repair must take into consideration the complex interplay between repair factors and the chromatin milieu in which they operate. This Research Topic collection, termed “DNA damage response in the context of chromatin”, brings together experts at the forefront of this emerging field with a series of authoritative reviews and exciting original articles to provide a timely update on our current understandings of biology at the intersection between chromatin and DNA repair.

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