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Vascularization in Bioartificial Parenchymal Tissue: Bioink and Bioprinting Strategies

Salg, Gabriel Alexander ; Blaeser, Andreas ; Gerhardus, Jamina Sofie ; Hackert, Thilo ; Kenngott, Hannes Goetz (2022):
Vascularization in Bioartificial Parenchymal Tissue: Bioink and Bioprinting Strategies. (Publisher's Version)
In: International Journal of Molecular Sciences, 23 (15), MDPI, e-ISSN 1422-0067,
DOI: 10.26083/tuprints-00022329,
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Item Type: Article
Origin: Secondary publication DeepGreen
Status: Publisher's Version
Title: Vascularization in Bioartificial Parenchymal Tissue: Bioink and Bioprinting Strategies
Language: English
Abstract:

Among advanced therapy medicinal products, tissue-engineered products have the potential to address the current critical shortage of donor organs and provide future alternative options in organ replacement therapy. The clinically available tissue-engineered products comprise bradytrophic tissue such as skin, cornea, and cartilage. A sufficient macro- and microvascular network to support the viability and function of effector cells has been identified as one of the main challenges in developing bioartificial parenchymal tissue. Three-dimensional bioprinting is an emerging technology that might overcome this challenge by precise spatial bioink deposition for the generation of a predefined architecture. Bioinks are printing substrates that may contain cells, matrix compounds, and signaling molecules within support materials such as hydrogels. Bioinks can provide cues to promote vascularization, including proangiogenic signaling molecules and cocultured cells. Both of these strategies are reported to enhance vascularization. We review pre-, intra-, and postprinting strategies such as bioink composition, bioprinting platforms, and material deposition strategies for building vascularized tissue. In addition, bioconvergence approaches such as computer simulation and artificial intelligence can support current experimental designs. Imaging-derived vascular trees can serve as blueprints. While acknowledging that a lack of structured evidence inhibits further meta-analysis, this review discusses an end-to-end process for the fabrication of vascularized, parenchymal tissue.

Journal or Publication Title: International Journal of Molecular Sciences
Volume of the journal: 23
Issue Number: 15
Place of Publication: Darmstadt
Publisher: MDPI
Collation: 25 Seiten
Uncontrolled Keywords: tissue engineering, regenerative medicine, bioprinting, vascularization, biomaterial, bioink, additive manufacturing, bioartificial organs
Classification DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit
600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften
Divisions: 16 Department of Mechanical Engineering > Institute of Printing Science and Technology (IDD) > Biomedical Printing Technology (BMT)
Interdisziplinäre Forschungsprojekte > Centre for Synthetic Biology
Date Deposited: 12 Sep 2022 13:15
Last Modified: 22 Sep 2022 07:17
DOI: 10.26083/tuprints-00022329
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-223298
Additional Information:

This article belongs to the Special Issue Tissue Engineering and Cell Therapy

SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/22329
PPN: 499563778
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