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Vascularization in Bioartificial Parenchymal Tissue: Bioink and Bioprinting Strategies

Salg, Gabriel Alexander ; Blaeser, Andreas ; Gerhardus, Jamina Sofie ; Hackert, Thilo ; Kenngott, Hannes Goetz (2022)
Vascularization in Bioartificial Parenchymal Tissue: Bioink and Bioprinting Strategies.
In: International Journal of Molecular Sciences, 2022, 23 (15)
doi: 10.26083/tuprints-00022329
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Vascularization in Bioartificial Parenchymal Tissue: Bioink and Bioprinting Strategies
Language: English
Date: 12 September 2022
Place of Publication: Darmstadt
Year of primary publication: 2022
Publisher: MDPI
Journal or Publication Title: International Journal of Molecular Sciences
Volume of the journal: 23
Issue Number: 15
Collation: 25 Seiten
DOI: 10.26083/tuprints-00022329
Corresponding Links:
Origin: Secondary publication DeepGreen

Among advanced therapy medicinal products, tissue-engineered products have the potential to address the current critical shortage of donor organs and provide future alternative options in organ replacement therapy. The clinically available tissue-engineered products comprise bradytrophic tissue such as skin, cornea, and cartilage. A sufficient macro- and microvascular network to support the viability and function of effector cells has been identified as one of the main challenges in developing bioartificial parenchymal tissue. Three-dimensional bioprinting is an emerging technology that might overcome this challenge by precise spatial bioink deposition for the generation of a predefined architecture. Bioinks are printing substrates that may contain cells, matrix compounds, and signaling molecules within support materials such as hydrogels. Bioinks can provide cues to promote vascularization, including proangiogenic signaling molecules and cocultured cells. Both of these strategies are reported to enhance vascularization. We review pre-, intra-, and postprinting strategies such as bioink composition, bioprinting platforms, and material deposition strategies for building vascularized tissue. In addition, bioconvergence approaches such as computer simulation and artificial intelligence can support current experimental designs. Imaging-derived vascular trees can serve as blueprints. While acknowledging that a lack of structured evidence inhibits further meta-analysis, this review discusses an end-to-end process for the fabrication of vascularized, parenchymal tissue.

Uncontrolled Keywords: tissue engineering, regenerative medicine, bioprinting, vascularization, biomaterial, bioink, additive manufacturing, bioartificial organs
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-223298
Additional Information:

This article belongs to the Special Issue Tissue Engineering and Cell Therapy

Classification DDC: 500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
600 Technology, medicine, applied sciences > 620 Engineering and machine engineering
Divisions: 16 Department of Mechanical Engineering > Institute of Printing Science and Technology (IDD) > Biomedical Printing Technology (BMT)
Interdisziplinäre Forschungsprojekte > Centre for Synthetic Biology
Date Deposited: 12 Sep 2022 13:15
Last Modified: 14 Nov 2023 19:05
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/22329
PPN: 499563778
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