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Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair

Kolobynina, Ksenia G. ; Rapp, Alexander ; Cardoso, M. Cristina (2022):
Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair. (Publisher's Version)
In: Frontiers in Cell and Developmental Biology, 10, Frontiers, e-ISSN 2296-634X,
DOI: 10.26083/tuprints-00022072,
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Item Type: Article
Origin: Secondary publication via sponsored Golden Open Access
Status: Publisher's Version
Title: Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair
Language: English
Abstract:

Chromatin is the context for all DNA-based molecular processes taking place in the cell nucleus. The initial chromatin structure at the site of the DNA damage determines both, lesion generation and subsequent activation of the DNA damage response (DDR) pathway. In turn, proceeding DDR changes the chromatin at the damaged site and across large fractions of the genome. Ubiquitination, besides phosphorylation and methylation, was characterized as an important chromatin post-translational modification (PTM) occurring at the DNA damage site and persisting during the duration of the DDR. Ubiquitination appears to function as a highly versatile “signal-response” network involving several types of players performing various functions. Here we discuss how ubiquitin modifiers fine-tune the DNA damage recognition and response and how the interaction with other chromatin modifications ensures cell survival.

Journal or Publication Title: Frontiers in Cell and Developmental Biology
Volume of the journal: 10
Place of Publication: Darmstadt
Publisher: Frontiers
Collation: 31 Seiten
Uncontrolled Keywords: chromatin, DNA damage response, DNA repair, double-strand breaks, ubiquitination
Classification DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
Divisions: 10 Department of Biology > Cell Biology and Epigenetics
Date Deposited: 24 Aug 2022 12:24
Last Modified: 26 Aug 2022 09:48
DOI: 10.26083/tuprints-00022072
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-220722
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/22072
PPN: 498634507
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