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Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors

Darvin, Maxim E. ; Lademann, Jürgen ; Hagen, Jörg von ; Lohan, Silke B. ; Kolmar, Harald ; Meinke, Martina C. ; Jung, Sora (2022):
Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors. (Publisher's Version)
In: Antioxidants, 11 (8), MDPI, e-ISSN 2076-3921,
DOI: 10.26083/tuprints-00021856,
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Item Type: Article
Origin: Secondary publication DeepGreen
Status: Publisher's Version
Title: Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors
Language: English
Abstract:

The antioxidant system of the human body plays a crucial role in maintaining redox homeostasis and has an important protective function. Carotenoids have pronounced antioxidant properties in the neutralization of free radicals. In human skin, carotenoids have a high concentration in the stratum corneum (SC)—the horny outermost layer of the epidermis, where they accumulate within lipid lamellae. Resonance Raman spectroscopy and diffuse reflectance spectroscopy are optical methods that are used to non-invasively determine the carotenoid concentration in the human SC in vivo. It was shown by electron paramagnetic resonance spectroscopy that carotenoids support the entire antioxidant status of the human SC in vivo by neutralizing free radicals and thus, counteracting the development of oxidative stress. This review is devoted to assembling the kinetics of the carotenoids in the human SC in vivo using non-invasive optical and spectroscopic methods. Factors contributing to the changes of the carotenoid concentration in the human SC and their influence on the antioxidant status of the SC in vivo are summarized. The effect of chemotherapy on the carotenoid concentration of the SC in cancer patients is presented. A potential antioxidant-based pathomechanism of chemotherapy-induced hand-foot syndrome and a method to reduce its frequency and severity are discussed.

Journal or Publication Title: Antioxidants
Volume of the journal: 11
Issue Number: 8
Place of Publication: Darmstadt
Publisher: MDPI
Collation: 31 Seiten
Uncontrolled Keywords: beta-carotene, lycopene, zeaxanthin, stratum corneum, antioxidant status, free radicals, reactive oxygen species, lipid oxygen species, aging, nutrition, diet, fruit and vegetables, Raman spectroscopy, diffuse reflectance spectroscopy, palmoplantar erythrodysesthesia, hand-foot syndrome
Classification DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit
Divisions: 07 Department of Chemistry > Fachgebiet Biochemie
Date Deposited: 03 Aug 2022 13:03
Last Modified: 01 Sep 2022 12:49
DOI: 10.26083/tuprints-00021856
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-218568
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/21856
PPN: 49875409X
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