Low-frequency vehicle acoustics are concerned with various aspects, from vehicle comfort to safety-relevant features of psychoacoustic origin. This includes concentration deficits and fatigue, which can affect the safety of the driver and other road users. Because of these potential risks, high additional weights are accepted for the detuning or vibration-damping of vehicle structures. Furthermore, high global dynamic stiffnesses are targeted in the early vehicle development phase by the vibroacoustics design. Besides the direct increase in weight, this causes mass-specific scaling effects in the entire product development process. Thus reinforcement by increasing wall thickness results in a higher body weight. If the chassis is heavier, the rollover scenario requires more stable pillars. Simultaneously powertrains and braking systems must be more powerful. Weight-intensive modifications in the early development phase trigger a chain reaction. The efficiency of the basic design regarding lightweight and acoustics must be improved by using a synergetic approach. After four decades of structural optimization the potential of conventional structure-based design methods has been exhausted in terms of lightweight efficiency. A more efficient prediction capability is offered by fluid-structure models, which allow perceptible targets to be predicted by sound pressure. However, the calculated sound predictions are subject to a high degree of scatter due to data, model and structural uncertainty. In case of missing targets, there are no common weight-neutral approaches for acoustic detuning in the validation process. Consequently, there is a high risk of subsequent mass applications. The aim of this work is to develop a method that identifies lightweight construction potentials in the effect chain of low-frequency acoustics (20-80 Hz) and to realize them through synergetic targeting. Sound pressure-based engineering with a fluid structure model is used to assign scopes to the parameters by global sensitivity analyses. Conflicting objectives are to be transformed into the best possible compromise through an optimization process. This prevents the implementation of disproportionate global stiffness and in addition to the immediate weight reduction avoids a mass scaling effect. Due to suitable sensitivity indices, levers for acoustical adjustment are activated in the early design phase. These levers enable weight-neutral influenceability of low-frequency acoustics for subsequent acoustic system tuning. As a Result, a weight-optimized basic design can be achieved and conventional, weight-intensive measures can be avoided. The inspiration for this new approach of engineering is outlined by a comprehensive analysis of the scientific environment as well as current trends in lightweight design and product development. After the con-cretization of the objective, the selection, justification and explanation of basic method modules for acoustic simulation and the applied sensitivity and optimization methods are presented. The further developed method modules are automated in a procedural approach. The development and validation of a representative validation model is used to confirm the functionality and to test the limits of this new design methodology. Finally, a pilot application is carried out on a purpose adapted vehicle model.