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Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism

Eills, J. ; Cavallari, E. ; Kircher, R. ; Di Matteo, G. ; Carrera, C. ; Dagys, L. ; Levitt, M. H. ; Ivanov, K. L. ; Aime, S. ; Reineri, F. ; Münnemann, K. ; Budker, D. ; Buntkowsky, Gerd ; Knecht, S. (2022):
Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism. (Publisher's Version)
In: Angewandte Chemie, 133 (12), pp. 6866-6873. Wiley, ISSN 0044-8249, e-ISSN 1521-3773,
DOI: 10.26083/tuprints-00020296,
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Item Type: Article
Origin: Secondary publication service
Status: Publisher's Version
Title: Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism
Language: English
Abstract:

Hyperpolarization-enhanced magnetic resonance imaging can be used to study biomolecular processes in the body, but typically requires nuclei such as ¹³C, ¹⁵N, or ¹²⁹Xe due to their long spin-polarization lifetimes and the absence of a proton-background signal from water and fat in the images. Here we present a novel type of ¹H imaging, in which hyperpolarized spin order is locked in a nonmagnetic long-lived correlated (singlet) state, and is only liberated for imaging by a specific biochemical reaction. In this work we produce hyperpolarized fumarate via chemical reaction of a precursor molecule with para-enriched hydrogen gas, and the proton singlet order in fumarate is released as antiphase NMR signals by enzymatic conversion to malate in D₂O. Using this model system we show two pulse sequences to rephase the NMR signals for imaging and suppress the background signals from water. The hyperpolarization-enhanced ¹H-imaging modality presented here can allow for hyperpolarized imaging without the need for low-abundance, low-sensitivity heteronuclei.

Journal or Publication Title: Angewandte Chemie
Volume of the journal: 133
Issue Number: 12
Publisher: Wiley
Classification DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Divisions: 07 Department of Chemistry > Physical Chemistry
Date Deposited: 10 Jan 2022 13:41
Last Modified: 10 Jan 2022 13:41
DOI: 10.26083/tuprints-00020296
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-202969
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/20296
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