Bogorodskiy, Andrey ; Okhrimenko, Ivan ; Burkatovskii, Dmitrii ; Jakobs, Philipp ; Maslov, Ivan ; Gordeliy, Valentin ; Dencher, Norbert A. ; Gensch, Thomas ; Voos, Wolfgang ; Altschmied, Joachim ; Haendeler, Judith ; Borshchevskiy, Valentin (2022):
Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases. (Publisher's Version)
In: Cells, 10 (12), MDPI, e-ISSN 2073-4409,
DOI: 10.26083/tuprints-00020276,
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Item Type: | Article |
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Origin: | Secondary publication DeepGreen |
Status: | Publisher's Version |
Title: | Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases |
Language: | English |
Abstract: | Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and two aqueous compartments. An extensive network of dedicated proteins is engaged in importing and sorting these nuclear-encoded proteins into their designated mitochondrial compartments. Defects in this fundamental system are related to a variety of pathologies, particularly engaging the most energy-demanding tissues. In this review, we summarize the state-of-the-art knowledge about the mitochondrial protein import machinery and describe the known interrelation of its failure with age-related neurodegenerative and cardiovascular diseases. |
Journal or Publication Title: | Cells |
Volume of the journal: | 10 |
Issue Number: | 12 |
Place of Publication: | Darmstadt |
Publisher: | MDPI |
Collation: | 22 Seiten |
Uncontrolled Keywords: | mitochondria, mitochondrial protein import, age-related diseases, Alzheimer’s disease, Parkinson’s disease, cardiovascular disease, TERT, cardiolipin |
Classification DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
Divisions: | 07 Department of Chemistry > Fachgebiet Biochemie |
Date Deposited: | 29 Apr 2022 09:10 |
Last Modified: | 10 Oct 2022 13:34 |
DOI: | 10.26083/tuprints-00020276 |
Corresponding Links: | |
URN: | urn:nbn:de:tuda-tuprints-202761 |
SWORD Depositor: | Deep Green |
URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/20276 |
PPN: | 500178038 |
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