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Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases

Bogorodskiy, Andrey ; Okhrimenko, Ivan ; Burkatovskii, Dmitrii ; Jakobs, Philipp ; Maslov, Ivan ; Gordeliy, Valentin ; Dencher, Norbert A. ; Gensch, Thomas ; Voos, Wolfgang ; Altschmied, Joachim ; Haendeler, Judith ; Borshchevskiy, Valentin (2022):
Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases. (Publisher's Version)
In: Cells, 10 (12), MDPI, e-ISSN 2073-4409,
DOI: 10.26083/tuprints-00020276,
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Item Type: Article
Origin: Secondary publication DeepGreen
Status: Publisher's Version
Title: Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases
Language: English
Abstract:

Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and two aqueous compartments. An extensive network of dedicated proteins is engaged in importing and sorting these nuclear-encoded proteins into their designated mitochondrial compartments. Defects in this fundamental system are related to a variety of pathologies, particularly engaging the most energy-demanding tissues. In this review, we summarize the state-of-the-art knowledge about the mitochondrial protein import machinery and describe the known interrelation of its failure with age-related neurodegenerative and cardiovascular diseases.

Journal or Publication Title: Cells
Volume of the journal: 10
Issue Number: 12
Publisher: MDPI
Collation: 22 Seiten
Uncontrolled Keywords: mitochondria, mitochondrial protein import, age-related diseases, Alzheimer’s disease, Parkinson’s disease, cardiovascular disease, TERT, cardiolipin
Classification DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
Divisions: 07 Department of Chemistry > Fachgebiet Biochemie
Date Deposited: 29 Apr 2022 09:10
Last Modified: 29 Apr 2022 09:11
DOI: 10.26083/tuprints-00020276
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-202761
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/20276
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