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The application of novel Ir-NHC polarization transfer complexes by SABRE

Hadjiali, Sara ; Bergmann, Marvin ; Kiryutin, Alexey ; Knecht, Stephan ; Sauer, Grit ; Plaumann, Markus ; Limbach, Hans-Heinrich ; Plenio, Herbert ; Buntkowsky, Gerd (2022):
The application of novel Ir-NHC polarization transfer complexes by SABRE. (Publisher's Version)
In: The Journal of Chemical Physics, 151 (24), AIP Publishing, ISSN 0021-9606, e-ISSN 1089-7690,
DOI: 10.26083/tuprints-00019737,
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Item Type: Article
Origin: Secondary publication service
Status: Publisher's Version
Title: The application of novel Ir-NHC polarization transfer complexes by SABRE
Language: English
Abstract:

In recent years, the hyperpolarization method Signal Amplification By Reversible Exchange (SABRE) has developed into a powerful technique to enhance Nuclear Magnetic Resonance (NMR) signals of organic substrates in solution (mostly via binding to the nitrogen lone pair of N-heterocyclic compounds) by several orders of magnitude. In order to establish the application and development of SABRE as a hyperpolarization method for medical imaging, the separation of the Ir-N-Heterocyclic Carbene (Ir-NHC) complex, which facilitates the hyperpolarization of the substrates in solution, is indispensable. Here, we report for the first time the use of novel Ir-NHC complexes with a polymer unit substitution in the backbone of N-Heterocyclic Carbenes (NHC) for SABRE hyperpolarization, which permits the removal of the complexes from solution after the hyperpolarization of a target substrate has been generated.

Journal or Publication Title: The Journal of Chemical Physics
Volume of the journal: 151
Issue Number: 24
Publisher: AIP Publishing
Collation: 7 Seiten
Classification DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Divisions: 07 Department of Chemistry > Physical Chemistry
Date Deposited: 11 Jan 2022 14:46
Last Modified: 11 Jan 2022 14:47
DOI: 10.26083/tuprints-00019737
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-197371
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19737
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