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Modeling Radioimmune Response — Current Status and Perspectives

Friedrich, Thomas ; Henthorn, Nicholas ; Durante, Marco (2024)
Modeling Radioimmune Response — Current Status and Perspectives.
In: Frontiers in Oncology, 2021, 11
doi: 10.26083/tuprints-00019589
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Type of entry: Secondary publication
Title: Modeling Radioimmune Response — Current Status and Perspectives
Language: English
Date: 12 March 2024
Place of Publication: Darmstadt
Year of primary publication: 16 March 2021
Place of primary publication: Lausanne
Publisher: Frontiers Media S.A.
Journal or Publication Title: Frontiers in Oncology
Volume of the journal: 11
Collation: 11 Seiten
DOI: 10.26083/tuprints-00019589
Corresponding Links:
Origin: Secondary publication DeepGreen

The combination of immune therapy with radiation offers an exciting and promising treatment modality in cancer therapy. It has been hypothesized that radiation induces damage signals within the tumor, making it more detectable for the immune system. In combination with inhibiting immune checkpoints an effective anti-tumor immune response may be established. This inversion from tumor immune evasion raises numerous questions to be solved to support an effective clinical implementation: These include the optimum immune drug and radiation dose time courses, the amount of damage and associated doses required to stimulate an immune response, and the impact of lymphocyte status and dynamics. Biophysical modeling can offer unique insights, providing quantitative information addressing these factors and highlighting mechanisms of action. In this work we review the existing modeling approaches of combined 'radioimmune' response, as well as associated fields of study. We propose modeling attempts that appear relevant for an effective and predictive model. We emphasize the importance of the time course of drug and dose delivery in view to the time course of the triggered biological processes. Special attention is also paid to the dose distribution to circulating blood lymphocytes and the effect this has on immune competence.

Uncontrolled Keywords: radiation immunity, immunotherapy, radiation therapy, modeling, radiation effect
Identification Number: Artikel-ID: 647272
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-195892
Additional Information:

This article is part of the Research Topic: Radiochemotherapy in Multimodal Cancer Therapy

Specialty section: This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Oncology

Classification DDC: 500 Science and mathematics > 530 Physics
600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 12 Mar 2024 13:20
Last Modified: 12 Mar 2024 13:20
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19589
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