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Entrapment of Hydrophobic Biocides into Cellulose Acetate Nanoparticles by Nanoprecipitation

Cordt, Cynthia ; Meckel, Tobias ; Geissler, Andreas ; Biesalski, Markus (2021)
Entrapment of Hydrophobic Biocides into Cellulose Acetate Nanoparticles by Nanoprecipitation.
In: Nanomaterials, 2020, 10 (12)
doi: 10.26083/tuprints-00019277
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Type of entry: Secondary publication
Title: Entrapment of Hydrophobic Biocides into Cellulose Acetate Nanoparticles by Nanoprecipitation
Language: English
Date: 13 August 2021
Place of Publication: Darmstadt
Year of primary publication: 2020
Publisher: MDPI
Journal or Publication Title: Nanomaterials
Volume of the journal: 10
Issue Number: 12
Collation: 15 Seiten
DOI: 10.26083/tuprints-00019277
Corresponding Links:
Origin: Secondary publication via sponsored Golden Open Access

This contribution reports an efficient method for the production and use of biocide-loaded cellulose acetate nanoparticles. As well-known model biocides 4-Hexylresorcinol and Triclosan were used for in situ nanoparticle loading during a nanoprecipitation process. We show that the nanoparticle size can be well-controlled by variation of the cellulose acetate concentration during nanoprecipitation. Apart from strong evidence suggesting cellulose acetate particle formation according to a nucleation-aggregation mechanism, we further show that the biocide loading of the particles occurs by a diffusion process and not via co-precipitation. The quantity of particle loading was analyzed by 1H-NMR spectroscopy of re-dissolved nanoparticles, and it was observed that a decisive factor for high packaging efficiency is the use of a biocide with low water solubility and high hydrophobicity. SEM studies showed no influence on the particle morphology or size by both biocides 4-Hexylresorcinol and Triclosan. Finally, an aqueous nanoparticle dispersion can be coated onto model paper sheets to yield pronounced antimicrobial surface-properties. Nanoparticles loaded with the biocide Triclosan showed a high antimicrobial activity against Bacillus subtilis, a cellulase producing bacteria, if applied to model paper substrates, even at extremely low coating weights of 1–5 g/m2, respectively. Additional long-term efficacy renders these nanoparticles ideal for various applications.

Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-192775
Classification DDC: 500 Science and mathematics > 540 Chemistry
Divisions: 07 Department of Chemistry > Ernst-Berl-Institut > Fachgebiet Makromolekulare Chemie
Date Deposited: 13 Aug 2021 07:10
Last Modified: 14 Nov 2023 19:03
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19277
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