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Polyelectrolyte Multilayers: Towards Single Cell Studies

Volodkin, Dmitry ; Klitzing, Regine von ; Moehwald, Helmuth (2021)
Polyelectrolyte Multilayers: Towards Single Cell Studies.
In: Polymers, 6 (5)
doi: 10.26083/tuprints-00019054
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 3.0 Unported - Creative Commons, Attribution.

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Item Type: Article
Type of entry: Secondary publication
Title: Polyelectrolyte Multilayers: Towards Single Cell Studies
Language: English
Date: 2021
Place of Publication: Darmstadt
Publisher: MDPI
Journal or Publication Title: Polymers
Volume of the journal: 6
Issue Number: 5
DOI: 10.26083/tuprints-00019054
Corresponding Links:
Origin: Secondary publication service

Single cell analysis (SCA) is nowadays recognized as one of the key tools for diagnostics and fundamental cell biology studies. The Layer-by-layer (LbL) polyelectrolyte assembly is a rather new but powerful technique to produce multilayers. It allows to model the extracellular matrix in terms of its chemical and physical properties. Utilization of the multilayers for SCA may open new avenues in SCA because of the triple role of the multilayer film: (i) high capacity for various biomolecules; (ii) natural mimics of signal molecule diffusion to a cell and (iii) cell patterning opportunities. Besides, light-triggered release from multilayer films offers a way to deliver biomolecules with high spatio-temporal resolution. Here we review recent works showing strong potential to use multilayers for SCA and address accordingly the following issues: biomolecule loading, cell patterning, and light-triggered release.

Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-190545
Classification DDC: 500 Science and mathematics > 530 Physics
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 03 Sep 2021 12:57
Last Modified: 08 Aug 2023 09:08
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19054
PPN: 510415679
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