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Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications

Bolze, Holger ; Riewe, Juliane ; Bunjes, Heike ; Dietzel, Andreas ; Burg, Thomas P. (2023)
Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications.
In: Chemical Engineering & Technology, 2021, 44 (3)
doi: 10.26083/tuprints-00017826
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Type of entry: Secondary publication
Title: Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications
Language: English
Date: 22 December 2023
Place of Publication: Darmstadt
Year of primary publication: 2021
Place of primary publication: Weinheim
Publisher: Wiley-VCH
Journal or Publication Title: Chemical Engineering & Technology
Volume of the journal: 44
Issue Number: 3
DOI: 10.26083/tuprints-00017826
Corresponding Links:
Origin: Secondary publication DeepGreen

Microfluidic processes are of great interest for the production of nanoparticles with reproducible properties. However, in real systems, it is difficult to completely exclude incidental production of larger particles, which can contaminate the product or clog downstream process modules. A class of microfluidic filters was devised for eliminating particulate contamination in multistage continuous‐flow processes. To achieve high throughput and filtration efficiency, a high‐surface‐area filter with an application‐adapted bonding method was developed. As a model application, the filtration efficiency was analyzed for lipid nanoparticles made by microfluidic antisolvent precipitation and the results were compared with requirements of the European and US guidelines.

Uncontrolled Keywords: In‐line filtration, Lipid nanoparticles, Membrane filtration, Nanoparticle synthesis, Precipitation
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-178263
Classification DDC: 600 Technology, medicine, applied sciences > 660 Chemical engineering
Divisions: 18 Department of Electrical Engineering and Information Technology > Integrated Micro- and Nanosystems
Date Deposited: 22 Dec 2023 13:42
Last Modified: 13 Mar 2024 07:08
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/17826
PPN: 516195816
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