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Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration

Luo, Xiaohe ; Lauwers, Marianne ; Layer, Paul G. ; Wen, Chunyi (2023)
Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration.
In: Frontiers in Cell and Developmental Biology, 2021, 8
doi: 10.26083/tuprints-00017779
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Type of entry: Secondary publication
Title: Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration
Language: English
Date: 5 December 2023
Place of Publication: Darmstadt
Year of primary publication: 2021
Place of primary publication: Lausanne
Publisher: Frontiers Media S.A.
Journal or Publication Title: Frontiers in Cell and Developmental Biology
Volume of the journal: 8
Collation: 12 Seiten
DOI: 10.26083/tuprints-00017779
Corresponding Links:
Origin: Secondary publication DeepGreen

Acetylcholinesterase (AChE), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. The expression of acetylcholinesterase and other cholinergic components is not restricted to only brain and nerve tissues but can also be found in non-neuronal tissues like the immune system and bone tissue. Primary identification of these components has been achieved. However, the information about their specific functions and underlying molecular mechanisms in bone remains scattered. Here, the physiological process of bone development, homeostasis, and degeneration are introduced. Next, the cholinergic system and its expression in bone tissue is documented. Among them, special attention goes to AChE, as the structure of this enzyme suggests diverse binding affinities, enabled by a peripheral site and a catalytic site. The peripheral site supports the non-enzymatic function of AChE in non-neuronal systems. Based on recent studies, the non-neuronal roles of acetylcholinesterase, both enzymatically and non-enzymatically, in bone development, homeostasis and degeneration are summarized briefly together with potential mechanisms to support these functions. We conclude that AChE may be a potential therapeutic target for bone diseases like osteoporosis.

Uncontrolled Keywords: acetylcholinesterase, bone development, bone homeostasis, bone degeneration, osteoporosis, non-enzymatic
Identification Number: 620543
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-177799
Classification DDC: 500 Science and mathematics > 570 Life sciences, biology
Divisions: 10 Department of Biology > Developmental Biology and Neurogenetics
Date Deposited: 05 Dec 2023 13:44
Last Modified: 07 Dec 2023 12:03
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/17779
PPN: 513688889
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