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In the past 20 years, mobile technologies and social media have not only been established in everyday life, but also in crises, disasters, and emergencies. Especially large-scale events, such as 2012 Hurricane Sandy or the 2013 European Floods, showed that citizens are not passive victims but active participants utilizing mobile and social information and communication technologies (ICT) for crisis response (Reuter, Hughes, et al., 2018). Accordingly, the research field of crisis informatics emerged as a multidisciplinary field which combines computing and social science knowledge of disasters and is rooted in disciplines such as human-computer interaction (HCI), computer science (CS), computer supported cooperative work (CSCW), and information systems (IS). While citizens use personal ICT to respond to a disaster to cope with uncertainty, emergency services such as fire and police departments started using available online data to increase situational awareness and improve decision making for a better crisis response (Palen & Anderson, 2016). When looking at even larger crises, such as the ongoing COVID-19 pandemic, it becomes apparent the challenges of crisis informatics are amplified (Xie et al., 2020). Notably, information is often not available in perfect shape to assist crisis response: the dissemination of high-volume, heterogeneous and highly semantic data by citizens, often referred to as big social data (Olshannikova et al., 2017), poses challenges for emergency services in terms of access, quality and quantity of information. In order to achieve situational awareness or even actionable information, meaning the right information for the right person at the right time (Zade et al., 2018), information must be refined according to event-based factors, organizational requirements, societal boundary conditions and technical feasibility. In order to research the topic of information refinement, this dissertation combines the methodological framework of design case studies (Wulf et al., 2011) with principles of design science research (Hevner et al., 2004). These extended design case studies consist of four phases, each contributing to research with distinct results. This thesis first reviews existing research on use, role, and perception patterns in crisis informatics, emphasizing the increasing potentials of public participation in crisis response using social media. Then, empirical studies conducted with the German population reveal positive attitudes and increasing use of mobile and social technologies during crises, but also highlight barriers of use and expectations towards emergency services to monitor and interact in media. The findings led to the design of innovative ICT artefacts, including visual guidelines for citizens’ use of social media in emergencies (SMG), an emergency service web interface for aggregating mobile and social data (ESI), an efficient algorithm for detecting relevant information in social media (SMO), and a mobile app for bidirectional communication between emergency services and citizens (112.social). The evaluation of artefacts involved the participation of end-users in the application field of crisis management, pointing out potentials for future improvements and research potentials. The thesis concludes with a framework on information refinement for crisis informatics, integrating event-based, organizational, societal, and technological perspectives.