TU Darmstadt / ULB / TUprints

cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4

Porro, Alessandro ; Thiel, Gerhard ; Moroni, Anna ; Saponaro, Andrea (2023)
cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4.
In: Frontiers in Physiology, 2020, 11
doi: 10.26083/tuprints-00016985
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

Download (814kB) | Preview
Item Type: Article
Type of entry: Secondary publication
Title: cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4
Language: English
Date: 5 December 2023
Place of Publication: Darmstadt
Year of primary publication: 2020
Place of primary publication: Lausanne
Publisher: Frontiers Media S.A.
Journal or Publication Title: Frontiers in Physiology
Volume of the journal: 11
Collation: 7 Seiten
DOI: 10.26083/tuprints-00016985
Corresponding Links:
Origin: Secondary publication DeepGreen

Direct regulation of the pacemaker "funny" current (If) by cyclic AMP (cAMP) underlies heart rate modulation by the autonomic nervous system. At the molecular level, cAMP activates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that drive If in sinoatrial node (SAN) myocytes. Even though HCN channel genes were identified more than 20 years ago, the understanding of how cAMP regulates their gating is still fragmented. Here we summarize present understanding on how the cAMP signal is transmitted from the cytosolic to the transmembrane (TM) domain in HCN4. We further discuss how detailed structural knowledge prompted the development of pharmacological/genetic tools for the control of cAMP regulation in these channels.

Uncontrolled Keywords: cyclic AMP, hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulation, structure, "funny" current, heart rate
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-169852
Additional Information:

This article is part of the Research Topic: Cardiac Pacemaking in Health and Disease: From Genes to Function

Classification DDC: 500 Science and mathematics > 570 Life sciences, biology
Divisions: 10 Department of Biology > Plant Membrane Biophyscis (20.12.23 renamed in Biology of Algae and Protozoa)
Date Deposited: 05 Dec 2023 13:36
Last Modified: 07 Dec 2023 12:07
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/16985
PPN: 513693459
Actions (login required)
View Item View Item