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Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study

Geisler, Ramsia ; Prévost, Sylvain ; Dattani, Rajeev ; Hellweg, Thomas (2022):
Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. (Publisher's Version)
In: Crystals, 10 (5), MDPI, e-ISSN 2073-4352,
DOI: 10.26083/tuprints-00016973,
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Item Type: Article
Origin: Secondary publication DeepGreen
Status: Publisher's Version
Title: Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study
Language: English
Abstract:

β-aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β-aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β-aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures.

Journal or Publication Title: Crystals
Volume of the journal: 10
Issue Number: 5
Publisher: MDPI
Collation: 15 Seiten
Uncontrolled Keywords: saponin, β-aescin, β-escin, lipid membrane, bicelle, nanodisk, wide-angle X-ray scattering, biosurfactant, ibuprofen
Classification DDC: 500 Naturwissenschaften und Mathematik > 530 Physik
500 Naturwissenschaften und Mathematik > 540 Chemie
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics > Soft Matter at Interfaces (SMI)
Date Deposited: 09 Feb 2022 15:18
Last Modified: 02 May 2022 12:07
DOI: 10.26083/tuprints-00016973
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-169736
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/16973
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