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Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study

Geisler, Ramsia ; Prévost, Sylvain ; Dattani, Rajeev ; Hellweg, Thomas (2022)
Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study.
In: Crystals, 2022, 10 (5)
doi: 10.26083/tuprints-00016973
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study
Language: English
Date: 2022
Place of Publication: Darmstadt
Year of primary publication: 2022
Publisher: MDPI
Journal or Publication Title: Crystals
Volume of the journal: 10
Issue Number: 5
Collation: 15 Seiten
DOI: 10.26083/tuprints-00016973
Corresponding Links:
Origin: Secondary publication DeepGreen
Abstract:

β-aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β-aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β-aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures.

Uncontrolled Keywords: saponin, β-aescin, β-escin, lipid membrane, bicelle, nanodisk, wide-angle X-ray scattering, biosurfactant, ibuprofen
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-169736
Classification DDC: 500 Science and mathematics > 530 Physics
500 Science and mathematics > 540 Chemistry
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics > Soft Matter at Interfaces (SMI)
Date Deposited: 09 Feb 2022 15:18
Last Modified: 08 Mar 2023 10:11
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/16973
PPN: 505576031
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