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The Many Faces of FKBP51

Hähle, Andreas ; Merz, Stephanie ; Meyners, Christian ; Hausch, Felix (2024)
The Many Faces of FKBP51.
In: Biomolecules, 2019, 9 (1)
doi: 10.26083/tuprints-00016874
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Type of entry: Secondary publication
Title: The Many Faces of FKBP51
Language: English
Date: 15 January 2024
Place of Publication: Darmstadt
Year of primary publication: 2019
Place of primary publication: Basel
Publisher: MDPI
Journal or Publication Title: Biomolecules
Volume of the journal: 9
Issue Number: 1
Collation: 20 Seiten
DOI: 10.26083/tuprints-00016874
Corresponding Links:
Origin: Secondary publication DeepGreen

The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and diabetes) and chronic pain. Recently, FKBP51 has been implicated in several cellular pathways and numerous interacting protein partners have been reported. However, no consensus on the underlying molecular mechanisms has yet emerged. Here, we review the protein interaction partners reported for FKBP51, the proposed pathways involved, their relevance to FKBP51’s physiological function(s), the interplay with other FKBPs, and implications for the development of FKBP51-directed drugs.

Uncontrolled Keywords: FKBP51, Hsp90, NF-κB, GR, glucocorticoids, FK506, SAFit
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-168749
Additional Information:

This article belongs to the Special Issue Evolving Functional Features of Peptidyl-Prolyl cis-trans Isomerases (PPIases) in Mono-Cellular versus Multi-Cellular Organisms

Classification DDC: 500 Science and mathematics > 540 Chemistry
500 Science and mathematics > 570 Life sciences, biology
Divisions: 07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie
Date Deposited: 15 Jan 2024 14:18
Last Modified: 27 Mar 2024 09:15
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/16874
PPN: 51653968X
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