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Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons

Simoniello, Palma ; Wiedemann, Julia ; Zink, Joana ; Thoennes, Eva ; Stange, Maike ; Layer, Paul G. ; Kovacs, Maximilian ; Podda, Maurizio ; Durante, Marco ; Fournier, Claudia (2024)
Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons.
In: Frontiers in Oncology, 2016, 5
doi: 10.26083/tuprints-00016217
Article, Secondary publication, Publisher's Version

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Item Type: Article
Type of entry: Secondary publication
Title: Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons
Language: English
Date: 8 March 2024
Place of Publication: Darmstadt
Year of primary publication: 8 January 2016
Place of primary publication: Lausanne
Publisher: Frontiers Media S.A.
Journal or Publication Title: Frontiers in Oncology
Volume of the journal: 5
Collation: 13 Seiten
DOI: 10.26083/tuprints-00016217
Corresponding Links:
Origin: Secondary publication DeepGreen
Abstract:

The increasing application of charged particles in radiotherapy requires a deeper understanding of early and late side effects occurring in skin, which is exposed in all radiation treatments. We measured cellular and molecular changes related to the early inflammatory response of human skin irradiated with carbon ions, in particular cell death induction and changes in differentiation and proliferation of epidermal cells during the first days after exposure. Model systems for human skin from healthy donors of different complexity, i.e., keratinocytes, coculture of skin cells, 3D skin equivalents, and skin explants, were used to investigate the alterations induced by carbon ions (spread-out Bragg peak, dose-averaged LET 100 keV/μm) in comparison to X-ray and UV-B exposure. After exposure to ionizing radiation, in none of the model systems, apoptosis/necrosis was observed. Carbon ions triggered inflammatory signaling and accelerated differentiation of keratinocytes to a similar extent as X-rays at the same doses. High doses of carbon ions were more effective than X-rays in reducing proliferation and inducing abnormal differentiation. In contrast, changes identified following low-dose exposure (≤0.5 Gy) were induced more effectively after X-ray exposure, i.e., enhanced proliferation and change in the polarity of basal cells.

Uncontrolled Keywords: human skin equivalent, keratinocytes, differentiation, apoptosis, inflammation, proliferation, ionizing irradiation, carbon ions
Identification Number: Artikel-ID: 294
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-162175
Additional Information:

This article is part of the Research Topic: Charged Particles in Oncology

Specialty section: This article was submitted to Radiation Oncology, a section of the journal Frontiers in Oncology

Classification DDC: 500 Science and mathematics > 530 Physics
500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions: 10 Department of Biology > Developmental Biology and Neurogenetics
10 Department of Biology > Radiation Biology and DNA Repair
05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 08 Mar 2024 13:13
Last Modified: 30 Apr 2024 15:40
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/16217
PPN: 517683296
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