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Carbon Ion Radiobiology

Tinganelli, Walter ; Durante, Marco (2022)
Carbon Ion Radiobiology.
In: Cancers, 2022, 12 (10)
doi: 10.26083/tuprints-00016188
Article, Secondary publication, Publisher's Version

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Type of entry: Secondary publication
Title: Carbon Ion Radiobiology
Language: English
Date: 9 February 2022
Place of Publication: Darmstadt
Year of primary publication: 2022
Publisher: MDPI
Journal or Publication Title: Cancers
Volume of the journal: 12
Issue Number: 10
Collation: 37 Seiten
DOI: 10.26083/tuprints-00016188
Corresponding Links:
Origin: Secondary publication DeepGreen

Radiotherapy using accelerated charged particles is rapidly growing worldwide. About 85% of the cancer patients receiving particle therapy are irradiated with protons, which have physical advantages compared to X-rays but a similar biological response. In addition to the ballistic advantages, heavy ions present specific radiobiological features that can make them attractive for treating radioresistant, hypoxic tumors. An ideal heavy ion should have lower toxicity in the entrance channel (normal tissue) and be exquisitely effective in the target region (tumor). Carbon ions have been chosen because they represent the best combination in this direction. Normal tissue toxicities and second cancer risk are similar to those observed in conventional radiotherapy. In the target region, they have increased relative biological effectiveness and a reduced oxygen enhancement ratio compared to X-rays. Some radiobiological properties of densely ionizing carbon ions are so distinct from X-rays and protons that they can be considered as a different “drug” in oncology, and may elicit favorable responses such as an increased immune response and reduced angiogenesis and metastatic potential. The radiobiological properties of carbon ions should guide patient selection and treatment protocols to achieve optimal clinical results.

Uncontrolled Keywords: carbon ions, particle therapy, radiotherapy, radiobiology, hypoxia, RBE, immunotherapy, metastasis
Status: Publisher's Version
URN: urn:nbn:de:tuda-tuprints-161883
Classification DDC: 500 Science and mathematics > 530 Physics
500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 09 Feb 2022 14:50
Last Modified: 14 Nov 2023 19:03
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/16188
PPN: 505575116
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