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Carbon Ion Radiobiology

Tinganelli, Walter ; Durante, Marco (2022):
Carbon Ion Radiobiology. (Publisher's Version)
In: Cancers, 12 (10), MDPI, e-ISSN 2072-6694,
DOI: 10.26083/tuprints-00016188,
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Item Type: Article
Origin: Secondary publication DeepGreen
Status: Publisher's Version
Title: Carbon Ion Radiobiology
Language: English
Abstract:

Radiotherapy using accelerated charged particles is rapidly growing worldwide. About 85% of the cancer patients receiving particle therapy are irradiated with protons, which have physical advantages compared to X-rays but a similar biological response. In addition to the ballistic advantages, heavy ions present specific radiobiological features that can make them attractive for treating radioresistant, hypoxic tumors. An ideal heavy ion should have lower toxicity in the entrance channel (normal tissue) and be exquisitely effective in the target region (tumor). Carbon ions have been chosen because they represent the best combination in this direction. Normal tissue toxicities and second cancer risk are similar to those observed in conventional radiotherapy. In the target region, they have increased relative biological effectiveness and a reduced oxygen enhancement ratio compared to X-rays. Some radiobiological properties of densely ionizing carbon ions are so distinct from X-rays and protons that they can be considered as a different “drug” in oncology, and may elicit favorable responses such as an increased immune response and reduced angiogenesis and metastatic potential. The radiobiological properties of carbon ions should guide patient selection and treatment protocols to achieve optimal clinical results.

Journal or Publication Title: Cancers
Volume of the journal: 12
Issue Number: 10
Publisher: MDPI
Collation: 37 Seiten
Uncontrolled Keywords: carbon ions, particle therapy, radiotherapy, radiobiology, hypoxia, RBE, immunotherapy, metastasis
Classification DDC: 500 Naturwissenschaften und Mathematik > 530 Physik
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 09 Feb 2022 14:50
Last Modified: 02 May 2022 12:07
DOI: 10.26083/tuprints-00016188
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-161883
SWORD Depositor: Deep Green
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/16188
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