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Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography

Abdighahroudi, Mohammad Sajjad ; Lutze, Holger V. ; Schmidt, Torsten C. (2022):
Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography. (Publisher's Version)
In: Analytical and Bioanalytical Chemistry, 412 (20), pp. 4921-4930. Springer, ISSN 1618-2642, e-ISSN 1618-2650,
DOI: 10.26083/tuprints-00013304,
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Item Type: Article
Origin: Secondary publication via DEAL-contract with Springer
Status: Publisher's Version
Title: Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography
Language: English
Abstract:

N-containing heterocycles (NCHs) are largely used as precursors for pharmaceuticals and can enter the environment. Some NCHs have been shown to be toxic, persistent, and very mobile in the environment. Thus, they have received increasing attention in the past years. However, the analysis of these polar compounds in environmental samples is still a challenge for liquid chromatography. This paper investigates the use of mixed-mode liquid chromatography (MMLC), which has reversed-phase and ion exchange characteristics for measurements of NCHs in water. NCHs with low pKa (i.e., < 2.5) display mainly reversed-phase interactions (neutral species) with the stationary phase and those with higher pKa (i.e., > 5) interact by a mixture of reversed-phase/ion exchange/HILIC mechanism. It was also shown that the presented method performs well in the quantification of the majority of the selected NCHs in surface water with MDLs between 3 and 6 μg/L, a low matrix effect and recoveries in the range of 77–96% except for pyridazine exhibiting 32% were achieved. The method was successfully employed to follow the degradation of NCHs in ozonation.

Journal or Publication Title: Analytical and Bioanalytical Chemistry
Volume of the journal: 412
Issue Number: 20
Publisher: Springer
Classification DDC: 600 Technik, Medizin, angewandte Wissenschaften > 600 Technik
600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften
Divisions: 13 Department of Civil and Environmental Engineering Sciences > Institute IWAR
Date Deposited: 03 Mar 2022 13:34
Last Modified: 03 Mar 2022 13:34
DOI: 10.26083/tuprints-00013304
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-133040
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/13304
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