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Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation

Rapp, Felicitas ; Simoniello, Palma ; Wiedemann, Julia ; Bahrami, Karola ; Grünebaum, Valeria ; Ktitareva, Svetlana ; Durante, Marco ; Lugenbiel, Patrick ; Thomas, Dierk ; Lehmann, Helge Immo ; Packer, Douglas L. ; Graeff, Christian ; Fournier, Claudia (2022):
Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation. (Publisher's Version)
In: Scientific Reports, 9, Springer Nature, e-ISSN 2045-2322,
DOI: 10.26083/tuprints-00013231,
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Item Type: Article
Origin: Secondary publication
Status: Publisher's Version
Title: Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation
Language: English
Abstract:

Noninvasive X-ray stereotactic treatment is considered a promising alternative to catheter ablation in patients affected by severe heart arrhythmia. High-energy heavy ions can deliver high radiation doses in small targets with reduced damage to the normal tissue compared to conventional X-rays. For this reason, charged particle therapy, widely used in oncology, can be a powerful tool for radiosurgery in cardiac diseases. We have recently performed a feasibility study in a swine model using high doses of high-energy C-ions to target specific cardiac structures. Interruption of cardiac conduction was observed in some animals. Here we report the biological effects measured in the pig heart tissue of the same animals six months after the treatment. Immunohistological analysis of the target tissue showed (1.) long-lasting vascular damage, i.e. persistent hemorrhage, loss of microvessels, and occurrence of siderophages, (2.) fibrosis and (3.) loss of polarity of targeted cardiomyocytes and wavy fibers with vacuolization. We conclude that the observed physiological changes in heart function are produced by radiation-induced fibrosis and cardiomyocyte functional inactivation. No effects were observed in the normal tissue traversed by the particle beam, suggesting that charged particles have the potential to produce ablation of specific heart targets with minimal side effects.

Journal or Publication Title: Scientific Reports
Volume of the journal: 9
Publisher: Springer Nature
Collation: 13 Seiten
Classification DDC: 500 Naturwissenschaften und Mathematik > 530 Physik
Divisions: 05 Department of Physics > Institute for condensed matter physics (2021 merged in Institute for Condensed Matter Physics) > Bio Physics
Date Deposited: 02 Mar 2022 09:32
Last Modified: 10 Mar 2022 09:39
DOI: 10.26083/tuprints-00013231
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-132312
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/13231
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