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Biotite: a unifying open source computational biology framework in Python

Kunzmann, Patrick ; Hamacher, Kay (2022):
Biotite: a unifying open source computational biology framework in Python. (Publisher's Version)
In: BMC Bioinformatics, 19, Springer Nature, ISSN 1471-2105,
DOI: 10.26083/tuprints-00012854,

Copyright Information: CC BY 4.0 International - Creative Commons, Attribution.

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Item Type: Article
Origin: Secondary publication via Golden Open Access
Status: Publisher's Version
Title: Biotite: a unifying open source computational biology framework in Python
Language: English

Background: As molecular biology is creating an increasing amount of sequence and structure data, the multitude of software to analyze this data is also rising. Most of the programs are made for a specific task, hence the user often needs to combine multiple programs in order to reach a goal. This can make the data processing unhandy, inflexible and even inefficient due to an overhead of read/write operations. Therefore, it is crucial to have a comprehensive, accessible and efficient computational biology framework in a scripting language to overcome these limitations. Results: We have developed the Python package Biotite: a general computational biology framework, that represents sequence and structure data based on NumPy ndarrays. Furthermore the package contains seamless interfaces to biological databases and external software. The source code is freely accessible at https://github.com/biotite-dev/biotite. Conclusions: Biotite is unifying in two ways: At first it bundles popular tasks in sequence analysis and structural bioinformatics in a consistently structured package. Secondly it adresses two groups of users: novice programmers get an easy access to Biotite due to its simplicity and the comprehensive documentation. On the other hand, advanced users can profit from its high performance and extensibility. They can implement their algorithms upon Biotite, so they can skip writing code for general functionality (like file parsers) and can focus on what their software makes unique.

Journal or Publication Title: BMC Bioinformatics
Volume of the journal: 19
Place of Publication: Darmstadt
Publisher: Springer Nature
Collation: 8 Seiten
Classification DDC: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
Divisions: 10 Department of Biology > Computational Biology and Simulation
Date Deposited: 01 Mar 2022 13:26
Last Modified: 20 Feb 2023 08:20
DOI: 10.26083/tuprints-00012854
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-128546
Additional Information:

Keywords: Open source, Python, NumPy, Structural biology, Sequence analysis

URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/12854
PPN: 505142120
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