Nanoscientific research has been characterized as an “engineering way of being in science.” This mode of research calls for a philosophy of technoscience that investigates the four questions: i) What is the role of theory and theory-development in nanoscale research, and what kinds of theories are needed for nanotechnological development? ii) What are the preferred methods and tools and the associated modes of reasoning in nanoscientific research? iii) What is nanotechnoscience and how are its objects constituted? iv) What kind of knowledge do technoscientific researchers typically produce and communicate? The consideration of these questions yields a survey of nanotechnoscience in terms of disciplinary questions (a complex field partially disclosed by stretching closed theories), of methodology (constructions and qualitative judgments of likeness), of ontology (a thin conception of nature as unlimited potential), and of epistemology (acquisition and demonstration of capabilities). In all four cases, the strictly philosophical discussion leads to societal dimensions and questions of value.