Constantinescu, Anna Maria
Planning studies for a non-invasive treatment of atrial fibrillation with scanned ion beams.
Technische Universität, Darmstadt
[Ph.D. Thesis], (2014)
Available under Creative Commons Attribution Non-commercial No Derivatives, 2.5.
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|Item Type:||Ph.D. Thesis|
|Title:||Planning studies for a non-invasive treatment of atrial fibrillation with scanned ion beams|
One treatment modality for atrial fibrillation, the most common cardiac arrhythmia, is radiofrequency catheter ablation in which fibrotic tissue is created around the pulmonary veins. The procedure has major drawbacks, hence a new treatment modality would be beneficial. This is the first in silico study for the feasibility of a non-invasive treatment of atrial fibrillation with scanned ion beams, which are successfully used in cancer radiotherapy. In collaboration with the Mayo Clinic (Rochester, Minnesota, USA) the first comparison between different irradiation techniques to cardiac target volumes was carried out in this work. In the presented results it was shown that the dose deposition to organs at risk could be drastically reduced compared to a potential non-invasive treatment of atrial fibrillation with photons. As a result of the actively applied ion beam, interference effects were observed when irradiating the moving cardiac volumes. The motion influences of respiration and heartbeat were studied individually and the resulting displacement was examined. To achieve a homogenous dose deposition in the moving target volumes, motion mitigation techniques (gating and rescanning) were successfully applied. The results will be validated in animal experiments at GSI in 2014.
|Place of Publication:||Darmstadt|
|Classification DDC:||500 Naturwissenschaften und Mathematik > 530 Physik|
|Divisions:||05 Department of Physics > Institute for condensed matter physics > Bio Physics|
|Date Deposited:||30 Oct 2014 12:43|
|Last Modified:||30 Oct 2014 12:43|
|Referees:||Durante, Prof. Dr. Marco and Bert, Prof. Dr. Christoph|
|Refereed:||25 April 2014|