Reparaturwege in Krebszellen gezielt ausschalten

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Item Type:	Article
Type of entry:	Secondary publication
Title:	Reparaturwege in Krebszellen gezielt ausschalten
Language:	German
Date:	16 January 2025
Place of Publication:	Darmstadt
Year of primary publication:	March 2022
Place of primary publication:	Berlin ; Heidelberg
Publisher:	Springer
Journal or Publication Title:	BIOspektrum : Das Magazin für Biowissenschaften
Volume of the journal:	28
Issue Number:	2
DOI:	10.26083/tuprints-00028528
Corresponding Links:	Publisher-DOI
Origin:	Secondary publication DeepGreen
Abstract:	Mutations in BRCA1 or BRCA2 are associated with breast, ovarian and other cancers. Cells with these mutations are defective in homologous recombination (HR), one of two main processes to repair DNA double-strand breaks (DSBs). Survival of these cells strongly relies on the usage of alternative repair pathways, such as POLθ-mediated end-joining (TMEJ). Thus, targeting TMEJ could be a promising new strategy for the therapy of BRCA1- and BRCA2-mutant tumours.
Status:	Publisher's Version
URN:	urn:nbn:de:tuda-tuprints-285288
Classification DDC:	500 Science and mathematics > 570 Life sciences, biology 600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions:	10 Department of Biology > Radiation Biology and DNA Repair
Date Deposited:	16 Jan 2025 10:06
Last Modified:	16 Jan 2025 10:07
SWORD Depositor:	Deep Green
URI:	https://tuprints.ulb.tu-darmstadt.de/id/eprint/28528
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