Lichtenthaeler, Chiara ; Oberstrass, Lasse ; Weigand, Julia E. (2024)
mRNA-Strukturen steuern die posttranskriptionelle Genregulation.
In: BIOspektrum : Das Magazin für Biowissenschaften, 2021, 27 (4)
doi: 10.26083/tuprints-00023544
Article, Secondary publication, Publisher's Version
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| Item Type: | Article |
|---|---|
| Type of entry: | Secondary publication |
| Title: | mRNA-Strukturen steuern die posttranskriptionelle Genregulation |
| Language: | German |
| Date: | 30 April 2024 |
| Place of Publication: | Darmstadt |
| Year of primary publication: | June 2021 |
| Place of primary publication: | Berlin ; Heidelberg |
| Publisher: | Springer |
| Journal or Publication Title: | BIOspektrum : Das Magazin für Biowissenschaften |
| Volume of the journal: | 27 |
| Issue Number: | 4 |
| DOI: | 10.26083/tuprints-00023544 |
| Corresponding Links: | |
| Origin: | Secondary publication DeepGreen |
| Abstract: | Posttranscriptional regulation at mRNA level is defined not only by sequence, but also by the structure of the mRNA. Structures in the untranslated regions control stability, translation and localization of an mRNA. Evolutionary conservation can be used to identify such regulatory active structures in mRNAs. For example, constitutive decay element (CDE) stem-loops are recognized by Roquin proteins in an exclusively shape-specific manner. Strikingly, some CDEs can serve a dual function in gene repression depending on their folding status. |
| Uncontrolled Keywords: | Life Sciences, general, Biochemistry, general, Human Genetics, Microbiology, Pharmacology/Toxicology |
| Status: | Publisher's Version |
| URN: | urn:nbn:de:tuda-tuprints-235444 |
| Classification DDC: | 500 Science and mathematics > 540 Chemistry 500 Science and mathematics > 570 Life sciences, biology |
| Divisions: | 10 Department of Biology > RNA Biochemistry |
| Date Deposited: | 30 Apr 2024 09:08 |
| Last Modified: | 04 Sep 2024 06:32 |
| SWORD Depositor: | Deep Green |
| URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/23544 |
| PPN: | 521053188 |
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