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For the present study numerical simulations of subcooled flow boiling of FC-72 in microgravity have been conducted to accompany boiling experiments performed in microgravity on the International Space Station (ISS). The numerical domain represents the geometry of the experimental test cell. For all simulations the open source framework OpenFOAM was employed, including extensions to the interFoam solver, which have been developed at the authors’ institute. A reference case has been defined applying intermediate values from the experimental parameter range as system parameters. This case has been examined thoroughly with regards to hydrodynamic phenomena and heat transfer during multiple, successive bubble cycles. Based on this reference case, the system parameters flow velocity, input heat flux, pre-heating time, and subcooling of the liquid bulk have been varied, and the impact of these quantities on bubble growth and movement as well as heat transfer have been studied. It was found, that an increased flow rate as well as increased subcooling lead to smaller bubbles and increased time between subsequent nucleations. A high input heat flux, an increased pre-heating time, and a decreased subcooling lead to a rapid cycle of bubble nucleation and coalescence.