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Polyelectrolyte Multilayers: Towards Single Cell Studies

Volodkin, Dmitry ; Klitzing, Regine von ; Moehwald, Helmuth (2021):
Polyelectrolyte Multilayers: Towards Single Cell Studies. (Publisher's Version)
In: Polymers, 6 (5), pp. 1502-1527. MDPI, e-ISSN 2073-4360,
DOI: 10.26083/tuprints-00019054,
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Item Type: Article
Origin: Secondary publication service
Status: Publisher's Version
Title: Polyelectrolyte Multilayers: Towards Single Cell Studies
Language: English
Abstract:

Single cell analysis (SCA) is nowadays recognized as one of the key tools for diagnostics and fundamental cell biology studies. The Layer-by-layer (LbL) polyelectrolyte assembly is a rather new but powerful technique to produce multilayers. It allows to model the extracellular matrix in terms of its chemical and physical properties. Utilization of the multilayers for SCA may open new avenues in SCA because of the triple role of the multilayer film: (i) high capacity for various biomolecules; (ii) natural mimics of signal molecule diffusion to a cell and (iii) cell patterning opportunities. Besides, light-triggered release from multilayer films offers a way to deliver biomolecules with high spatio-temporal resolution. Here we review recent works showing strong potential to use multilayers for SCA and address accordingly the following issues: biomolecule loading, cell patterning, and light-triggered release.

Journal or Publication Title: Polymers
Journal volume: 6
Number: 5
Publisher: MDPI
Classification DDC: 500 Naturwissenschaften und Mathematik > 530 Physik
Divisions: 05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 03 Sep 2021 12:57
Last Modified: 03 Sep 2021 12:57
DOI: 10.26083/tuprints-00019054
Corresponding Links:
URN: urn:nbn:de:tuda-tuprints-190545
URI: https://tuprints.ulb.tu-darmstadt.de/id/eprint/19054
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