Porro, Alessandro ; Thiel, Gerhard ; Moroni, Anna ; Saponaro, Andrea (2023)
cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4.
In: Frontiers in Physiology, 2020, 11
doi: 10.26083/tuprints-00016985
Article, Secondary publication, Publisher's Version
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| Item Type: | Article |
|---|---|
| Type of entry: | Secondary publication |
| Title: | cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4 |
| Language: | English |
| Date: | 5 December 2023 |
| Place of Publication: | Darmstadt |
| Year of primary publication: | 2020 |
| Place of primary publication: | Lausanne |
| Publisher: | Frontiers Media S.A. |
| Journal or Publication Title: | Frontiers in Physiology |
| Volume of the journal: | 11 |
| Collation: | 7 Seiten |
| DOI: | 10.26083/tuprints-00016985 |
| Corresponding Links: | |
| Origin: | Secondary publication DeepGreen |
| Abstract: | Direct regulation of the pacemaker "funny" current (If) by cyclic AMP (cAMP) underlies heart rate modulation by the autonomic nervous system. At the molecular level, cAMP activates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that drive If in sinoatrial node (SAN) myocytes. Even though HCN channel genes were identified more than 20 years ago, the understanding of how cAMP regulates their gating is still fragmented. Here we summarize present understanding on how the cAMP signal is transmitted from the cytosolic to the transmembrane (TM) domain in HCN4. We further discuss how detailed structural knowledge prompted the development of pharmacological/genetic tools for the control of cAMP regulation in these channels. |
| Uncontrolled Keywords: | cyclic AMP, hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulation, structure, "funny" current, heart rate |
| Status: | Publisher's Version |
| URN: | urn:nbn:de:tuda-tuprints-169852 |
| Additional Information: | This article is part of the Research Topic: Cardiac Pacemaking in Health and Disease: From Genes to Function |
| Classification DDC: | 500 Science and mathematics > 570 Life sciences, biology |
| Divisions: | 10 Department of Biology > Plant Membrane Biophyscis (20.12.23 renamed in Biology of Algae and Protozoa) |
| Date Deposited: | 05 Dec 2023 13:36 |
| Last Modified: | 07 Dec 2023 12:07 |
| SWORD Depositor: | Deep Green |
| URI: | https://tuprints.ulb.tu-darmstadt.de/id/eprint/16985 |
| PPN: | 513693459 |
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