Additional File 8 Molecule activity prediction using Ingenuity Pathway Analysis Molecule activity prediction using Ingenuity Pathway Analysis. Mitotic Roles of Polo-Like Kinase after 2 Gray, model 1 (considering age at sampling and sex). Left: fibroblasts of donors with at least one second primary neoplasm, right: childhood cancer survivors without a second primary neoplasm Additional File 8a 3 Molecule activity prediction using Ingenuity Pathway Analysis. p53 Signaling after 0.05 Gray, model 1 (considering age at sampling and sex). Left to right: fibroblasts of donors with at least one second primary neoplasm, childhood cancer survivors, and cancer-free donors. (Only adjusted p-value < 0.05 in fibroblasts of cancer-free donors) Additional File 8b 4 Molecule activity prediction using Ingenuity Pathway Analysis. p53 Signaling after 2 Gray, model 1 (considering age at sampling and sex). Left to right: fibroblasts of donors with at least one second primary neoplasm, childhood cancer survivors, cancer-free controls Additional File 8c 5 Molecule activity prediction using Ingenuity Pathway Analysis. Molecular Mechanisms of Cancer after 2 Gray, model 1 (considering age at sampling and sex). Left to right: in fibroblasts of donors with at least one second primary neoplasm, childhood cancer survivors, cancer-free controls. Additional File 8d 6 Molecule activity prediction using Ingenuity Pathway Analysis. DNA Double-Strand Break Repair by Homologous Recombination after 2 Gray, model 1 (considering age at sampling and sex) in fibroblasts of donors with at least one second primary neoplasm. Additional File 8e 7 Molecule activity prediction using Ingenuity Pathway Analysis. Chronic Myeloid Leukemia Signaling after 2 Gray, model 1 (considering age at sampling and sex) in fibroblasts of donors with at least one second primary neoplasm (left) and cancer-free controls (right). Additional File 8f 8 Molecule activity prediction using Ingenuity Pathway Analysis. Hereditary Breast Cancer Signaling after 2 Gray, model 1 (considering age at sampling and sex) in fibroblasts of donors with at least one second primary neoplasm (left) and cancer-free controls (right). Additional File 8g 9 Molecule activity prediction using Ingenuity Pathway Analysis. Prostate Cancer Signaling after 2 Gray, model 1 (considering age at sampling and sex) in fibroblasts of childhood cancer survivors without a second neoplasm. Additional File 8h 10 image1.png image2.jpeg image3.jpeg image4.jpeg image5.jpeg image6.jpeg image7.jpeg image8.jpeg image9.jpeg image10.jpeg image11.jpeg image12.jpeg image13.jpeg image14.jpeg image15.jpeg image16.jpeg image17.jpg image18.jpeg